Neurodegeneration and cell replacement.

Neurodegeneration and cell replacement. Research Abstract Details 

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Neurodegeneration and cell replacement. Abstract Text:

Brandi K Ormerod,Theo D Palmer,Maeve A Caldwell,Brandi K Ormerod,Theo D Palmer,Maeve A Caldwell,

The past decade has witnessed ground-breaking advances in human stem cell biology with scientists validating adult neurogenesis and establishing methods to isolate and propagate stem cell populations suitable for transplantation. These advances have forged promising strategies against human neurodegenerative diseases. For example, growth factor administration could stimulate intrinsic repair from endogenous neural stem cells, and cultured stem cells engineered into biopumps could be transplanted to deliver neuroprotective or restorative agents. Stem cells could also be transplanted to generate new neural elements that augment and potentially replace degenerating central nervous system (CNS) circuitry. Early efforts in neural tissue transplantation have shown that these strategies can improve functional outcome, but the ultimate success of clinical stem cell-based strategies will depend on detailed understanding of stem cell biology in the degenerating brain and detailed evaluation of their functional efficacy and safety in preclinical animal models.

Neurodegeneration and cell replacement. Publishing Authors By Initials

BK Ormerod,TD Palmer,MA Caldwell,BK Ormerod,TD Palmer,MA Caldwell,

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Neurodegeneration and cell replacement. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Philosophical transactions of the Royal Society of

VOLUME: 363

Page Numbers: 153-70

Journal Abbreviation: Philos. Trans. R. Soc. Lond.,

ISSN: 0962-8436

DAY: 29

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Neurodegeneration and cell replacement.

AFFILIATION: Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Boswell Building, A301, Stanford, CA 94305-5327, USA.

Country: England

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MEDLINETA: Philos Trans R Soc Lond B Biol

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