Neuroblast specification and formation regulated by wingless in the Drosophila CNS.

Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Research Abstract Details 

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Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Abstract Text:

The Drosophila central nervous system (CNS) develops from a heterogeneous population of neural stem cells (neuroblasts), yet the genes regulating neuroblast determination remain unknown. The segmentation gene wingless is regionally expressed in the neuroectoderm from which neuroblasts develop. A conditional wingless mutation is used to inactivate CNS function without affecting segmentation. The stripe of wingless-expressing neuroectoderm generates apparently normal neuroblasts after wingless inactivation; however, adjacent anterior and posterior neuroectoderm requires wingless nonautonomously for subsequent neuroblast determination and formation. Loss of wingless results in the absence or duplication of identified neuroblasts, highlighting its role in generating neuroblast diversity in the CNS.

Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Publishing Authors By Initials

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Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Science (New York, N.Y.)

VOLUME: 261

Page Numbers: 1594-7

Journal Abbreviation: Science

ISSN: 0036-8075

DAY: 17

MONTH: Sep

YEAR: 1993

Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Information

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LANGUAGE: eng

NlmUniqueID: 404511

Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: cytology

Chemical & Substance for Abstract: Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Information

Substance Name: wg protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Neuroblast specification and formation regulated by wingless in the Drosophila CNS.

AFFILIATION: Department of Cell and Structural Biology, University of Illinois, Urbana 61801.

Country: UNITED STATES

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MEDLINETA: Science

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