[Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)]

[Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)] Research Abstract Details 

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[Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)] Abstract Text:

This experiment was designed to study the degree of recovery from lead-induced neuro-behavioral deficit after normalization of blood lead-level (PbB). Female Wistar-rats were given a diet containing lead-acetate (2260 ppm Pb) for 60 d until mating, giving rise to a PbB-increase from 53 microgram/d1 (before mating) to 84 microgram/d1 (after weaning). Lead-exposure of their male offspring was continued for 4 months with their PbB levelling off at 40 microgram/d1 (table 1). Lead-feeding was discontinued thereafter for another 4 months, PbB declining to a final level of 12 microgram/d1 (table 1). These animals were then compared for neurobehavioral functions to age-matched controls with respect to discrimination-learning (Lashley jumping-stand) and motor activity (open field-test). In addition recovery from initial loss of body-weight after partial food-deprivation was measured, known to be retarded at elevated PbB. The results may be summarized as follows: Formerly Pb-treated animals subsequently raised on a lead-free diet resulting in PbB-normalization within 4 months as compared to untreated controls exhibit (1) significant retardation of recovery from initial loss of body-weight (fig 4), (2) significant increase of error-repetitions in discrimination-learning (table 4; fig. 5) indicating disturbances of learning-performance without a change in learning-speed, and (3) significant hypoactivity (ambulation) without a significant change of other variables of open field-behavior (table 5; fig. 6). These results demonstrate, that some neurobehavioral and systemic symptoms of Pb-related dysfunction persist even after normalization of PbB, thus indicating partial irreversibility of Pb-induced damage.

[Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)] Publishing Authors By Initials

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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[Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zentralblatt für Bakteriologie. 1. Abt. Originale

VOLUME: 170

Page Numbers: 353-67

Journal Abbreviation:

ISSN: 0172-5602

DAY: 4

MONTH: 03

YEAR: 1980

[Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)] Information

Number of References:

LANGUAGE: ger

NlmUniqueID: 8005749

[Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)] Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: drug effects

Chemical & Substance for Abstract: [Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)] Information

Substance Name: Lead

Registry Number: 7439-92-1

Grant and Affiliation Information for [Neurobehavioral and systemic effects in lead-exposed rats after an exposure-free interval of four months duration (author's transl)]

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Country: GERMANY, WEST

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MEDLINETA: Zentralbl Bakteriol [B]

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