Neuroanatomical phenotypes in the reeler mouse.

Neuroanatomical phenotypes in the reeler mouse. Research Abstract Details 

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Neuroanatomical phenotypes in the reeler mouse. Abstract Text:

Alexandra Badea,Peter J Nicholls,G Allan Johnson,William C Wetsel,

The reeler mouse (Reln) has been proposed as a neurodevelopmental model for certain neurological and psychiatric conditions and has been studied by qualitative histochemistry and electron microscopy. Using magnetic resonance microscopy (MRM), we have quantitated for the first time the neuromorphology of Reln mice at a resolution of 21.5 microm. The neuroanatomical phenotypes of heterozygous and homozygous mutant Reln mice were compared to those of wild type (WT) littermates using morphometry and texture analysis. The cortical, hippocampal, and cerebellar phenotypes of the heterozygous and homozygous mutant Reln mice were confirmed, and new features were revealed. The Reln(rl/rl) mice possessed a smaller brain, and both Reln(rl/+) and Reln(rl/rl) mice had increased ventricles compared to WT controls. Shape differences were found between WT and Reln(rl/rl) brains, specifically in cerebellum, olfactory bulbs, dorsomedial frontal and parietal cortex, certain regions of temporal and occipital lobes, as well as in the lateral ventricles and ventral hippocampus. These findings suggest that certain brain regions may be more severely impacted by the Reln mutation than others. Gadolinium-based active staining demonstrated that layers of the hippocampus were disorganized in Reln(rl/rl) mice and differences in thickness of these layers were identified between WT and Reln(rl/rl) mice. The intensity distributions characteristic to the dorsal, middle, and ventral hippocampus were altered in the Reln(rl/rl), especially in the ventral hippocampus. These differences were quantified using skewness and modeling the intensity distributions with a Gaussian mixture. Our results suggest that structural features of Reln(rl/rl) brain most closely phenocopy those of patients with Norman-Roberts lissencephaly.

Neuroanatomical phenotypes in the reeler mouse. Publishing Authors By Initials

A Badea,PJ Nicholls,GA Johnson,WC Wetsel,

For similar genetic phenomena: phenotype research abstracts see: genetic phenomena: phenotype research

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Neuroanatomical phenotypes in the reeler mouse. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: NeuroImage

VOLUME: 34

Page Numbers: 1363-74

Journal Abbreviation: Neuroimage

ISSN: 1053-8119

DAY: 20

MONTH: 12

YEAR: 2006

Neuroanatomical phenotypes in the reeler mouse. Information

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LANGUAGE: eng

NlmUniqueID: 9215515

Neuroanatomical phenotypes in the reeler mouse. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: genetics

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Grant and Affiliation Information for Neuroanatomical phenotypes in the reeler mouse.

AFFILIATION: Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA.

Country: United States

AGENCY: United States NCRR

GRANT: U24 RR021760

ACRONYM: RR

MEDLINETA: Neuroimage

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