Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study.

Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Abstract Text:

Helen Lavretsky,Martina Ballmaier,Daniel Pham,Arthur Toga,Anand Kumar,

OBJECTIVE: Apathy is one of the most common late-life neuropsychiatric syndromes. The objective of our study was to examine the neuroanatomical correlates of apathy in older subjects with and without geriatric major depression (MDD). METHODS: Eighty-four subjects (43 patients with MDD and 41 normal comparison subjects) underwent comprehensive neuropsychiatric examination, physical examination, and high-resolution magnetic resonance imaging (MRI) brain scans on a 1.5T GE MRI scanner. Apathy was assessed using the Apathy Evaluation Scale. MRI image analyses included cortical surface extraction, tissue segmentation, and cortical parcellation methods to measure the gray and white matter volumes in two prefrontal subregions: the anterior cingulate and orbitofrontal cortex. RESULTS: The depressed group had smaller orbitofrontal gray matter volumes compared to the age-matched normal comparison group. The severity of apathy was associated with the decreased gray matter volume in the right anterior cingulate gray matter volumes using partial correlation and regression analyses after controlling for age, sex, and diagnosis. CONCLUSION: Apathy and depression were associated with different anatomical correlates in the prefrontal regions implicated in the regulation of cognition and emotion. Our findings offer new understanding of the neuroanatomical characteristics of apathy and depression in late life, and have broad implications for the neurobiology of behavior.

Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Publishing Authors By Initials

H Lavretsky,M Ballmaier,D Pham,A Toga,A Kumar,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: frontal lobe: prefrontal cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: frontal lobe: prefrontal cortex research

PUBMED ID PMID:

MEDLINE DATE:

Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of geriatric psychiatry : off

VOLUME: 15

Page Numbers: 386-94

Journal Abbreviation:

ISSN: 1064-7481

DAY: 3

MONTH: May

YEAR: 2007

Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9309609

Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Keywords Mesh Terms:

KEYWORDS: Prefrontal Cortex

MESH TERMS: pathology

Chemical & Substance for Abstract: Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study.

AFFILIATION: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. hlavrets@ucla.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH55115

ACRONYM: MH

MEDLINETA: Am J Geriatr Psychiatry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study Related Publications

• A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas.
• A new paradigm for the treatment of high-risk prostate cancer: radiosensitization with docetaxel.
• An inherent role of microtubule network in the action of nuclear receptor.
• Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude.
• Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer.
• Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action.
• Cognitive function in adults with type 2 diabetes and major depression.
• Diagnosis and management of extensive vertex birth molding.
• Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
• Effect of individual and multiple antioxidant vitamins on growth and morphology of human nontumorigenic and tumorigenic parotid acinar cells in culture.
• Functional analysis of alternative isoforms of the transcription factor PAX3 in melanocytes in vitro.
• HPA axis activity and neuropathogenesis in HIV-1 clade C infection.
• How substance use differs among American secondary schools.
• Influence of Agrobacterium rhizogenes Strains on Biomass and Alkaloid Productivity in Hairy Root Lines of Hyoscyamus muticus and H. albus *.
• Letter to the editor: The suckling-micturition reflex in cows.
• Metal-binding properties of human centrin-2 determined by micro-electrospray ionization mass spectrometry and UV spectroscopy.
• Metastasis tumor antigens, an emerging family of multifaceted master coregulators.
• Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.
• Modification of the expression of adenosine 3',5'-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate.
• P21-activated kinases in human cancer.
• Pituitary abscess: Report of four cases and review of literature.
• Potential medicinal plants for CNS disorders: an overview.
• Protein disulfide isomerase assisted protein folding in malaria parasites.
• Quality of life in HIV subtype C infection among asymptomatic subjects and its association with CD4 counts and viral loads--a study from South India.
• Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
• Sexual differentiation and development in the malaria parasite.
• Standard wound coverage techniques for extremity war injury.
• Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.
• Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV.
• p21-activated kinase signaling in breast cancer.