Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.

Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Research Abstract Details 

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Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Abstract Text:

Asuka Iwanaga,Tokiharu Sato,Kazushi Sugihara,Atsushi Hirao,Nobuyuki Takakura,Hiroshi Okamoto,Masahide Asano,Katsuji Yoshioka,Asuka Iwanaga,Tokiharu Sato,Kazushi Sugihara,Atsushi Hirao,Nobuyuki Takakura,Hiroshi Okamoto,Masahide Asano,Katsuji Yoshioka,

We previously identified c-Jun NH(2)-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1, also known as JNK-interacting protein 3) as a scaffolding factor for JNK intracellular signaling pathways. Targeted gene-disruption studies have shown that JSAP1-null mice are unable to breathe and die shortly after birth. Although neural defects might be responsible for their death, there has been no convincing evidence for this. Here we first generated genetically engineered mice carrying a loxP-flanked (floxed) jsap1 gene. To evaluate the validity of this deletion as a jsap1 conditional knockout (KO), we created mice in which the same exon was deleted in all cell lineages, and compared their phenotypes with those of the jsap1 conventional KO mice reported previously. The two KO lines showed indistinguishable phenotypes, i.e., neonatal death and morphological defects in the telencephalon, indicating that the conditional deletion was a true null mutation. We then introduced the floxed jsap1 deletion mutant specifically into the neural lineage, and found that the jsap1 conditional KO mice showed essentially the same phenotypes as the JSAP1-null mice. These results strongly suggest that the neonatal death of jsap1-deficient mice is caused by defects in the nervous system.

Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Publishing Authors By Initials

A Iwanaga,T Sato,K Sugihara,A Hirao,N Takakura,H Okamoto,M Asano,K Yoshioka,A Iwanaga,T Sato,K Sugihara,A Hirao,N Takakura,H Okamoto,M Asano,K Yoshioka,

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Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience letters

VOLUME: 429

Page Numbers: 43-8

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 2

MONTH: 10

YEAR: 2007

Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Information

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LANGUAGE: eng

NlmUniqueID: 7600130

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AFFILIATION: Division of Molecular Cell Signaling, Department of Molecular and Cellular Biology, Cancer Research Institute, Kanazawa University, Ishikawa 920-0934, Japan.

Country: Ireland

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MEDLINETA: Neurosci Lett

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