Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPalpha.

Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPalpha. Research Abstract Details 

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Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPalpha. Abstract Text:

Haihong Ye,Yen Ling Jessie Tan,Sathivel Ponniah,Yasuo Takeda,Shi-Qiang Wang,Melitta Schachner,Kazutada Watanabe,Catherine J Pallen,Zhi-Cheng Xiao,Haihong Ye,Yen Ling Jessie Tan,Sathivel Ponniah,Yasuo Takeda,Shi-Qiang Wang,Melitta Schachner,Kazutada Watanabe,Catherine J Pallen,Zhi-Cheng Xiao,

Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. Neural recognition molecule Close Homolog of L1 (CHL1) has been shown to regulate oriented growth of apical dendrites in the mouse caudal cortex. Here we show that CHL1 directly associates with NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. Similar to CHL1, NB-3 exhibits high-caudal to low-rostral expression in the deep layer neurons of the neocortex. NB-3-deficient mice show abnormal apical dendrite projections of deep layer pyramidal neurons in the visual cortex. Both CHL1 and NB-3 interact with protein tyrosine phosphatase alpha (PTPalpha) and regulate its activity. Moreover, deep layer pyramidal neurons of PTPalpha-deficient mice develop misoriented, even inverted, apical dendrites. We propose a signaling complex in which PTPalpha mediates CHL1 and NB-3-regulated apical dendrite projection in the developing caudal cortex.

Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPalpha. Publishing Authors By Initials

H Ye,YL Tan,S Ponniah,Y Takeda,SQ Wang,M Schachner,K Watanabe,CJ Pallen,ZC Xiao,H Ye,YL Tan,S Ponniah,Y Takeda,SQ Wang,M Schachner,K Watanabe,CJ Pallen,ZC Xiao,

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Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPalpha. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 27

Page Numbers: 188-200

Journal Abbreviation: EMBO J.

ISSN: 1460-2075

DAY: 29

MONTH: 11

YEAR: 2007

Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPalpha. Information

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LANGUAGE: eng

NlmUniqueID: 8208664

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Grant and Affiliation Information for Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPalpha.

AFFILIATION: Institute of Molecular and Cell Biology, Singapore, Singapore.

Country: England

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MEDLINETA: EMBO J

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