Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals.

Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Research Abstract Details 

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Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Abstract Text:

P M White,S J Morrison,K Orimoto,C J Kubu,J M Verdi,D J Anderson,

Rat neural crest stem cells (NCSCs) prospectively isolated from uncultured E14.5 sciatic nerve and transplanted into chick embryos generate fewer neurons than do NCSCs isolated from E10.5 neural tube explants. In addition, they differentiate primarily to cholinergic parasympathetic neurons, although in culture they can also generate noradrenergic sympathetic neurons. This in vivo behavior can be explained, at least in part, by a reduced sensitivity of sciatic nerve-derived NCSCs to the neurogenic signal BMP2 and by the observation that cholinergic neurons differentiate at a lower BMP2 concentration than do noradrenergic neurons in vitro. These results demonstrate that neural stem cells can undergo cell-intrinsic changes in their sensitivity to instructive signals, while maintaining multipotency and self-renewal capacity. They also suggest that the choice between sympathetic and parasympathetic fates may be determined by the local concentration of BMP2.

Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Publishing Authors By Initials

PM White,SJ Morrison,K Orimoto,CJ Kubu,JM Verdi,DJ Anderson,

For similar surgical procedures, operative: transplantation: transplantation, heterologous research abstracts see: surgical procedures, operative: transplantation: transplantation, heterologous research

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Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuron

VOLUME: 29

Page Numbers: 57-71

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 19

MONTH: Jan

YEAR: 2001

Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Keywords Mesh Terms:

KEYWORDS: Transplantation, Heterologous

MESH TERMS: embryology

Chemical & Substance for Abstract: Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Information

Substance Name: Acetylcholine

Registry Number: 51-84-3

Grant and Affiliation Information for Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals.

AFFILIATION: Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA.

Country: United States

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MEDLINETA: Neuron

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