Netrin-1 is a novel myelin-associated inhibitor to axon growth.

Netrin-1 is a novel myelin-associated inhibitor to axon growth. Research Abstract Details 

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Netrin-1 is a novel myelin-associated inhibitor to axon growth. Abstract Text:

Karin Löw,Maya Culbertson,Frank Bradke,Marc Tessier-Lavigne,Mark H Tuszynski,Karin Löw,Maya Culbertson,Frank Bradke,Marc Tessier-Lavigne,Mark H Tuszynski,

We investigated the influence of the bifunctional guidance molecule netrin-1 on axonal growth in the injured adult spinal cord. In the adult, netrin-1 is expressed on mature oligodendrocytes, cells of the central canal, and the meninges. Netrin-1 protein in white matter is selectively enriched adjacent to paranodal loops of myelin in nodes of Ranvier. The repulsion-mediating netrin-1 uncoordinated-5 (UNC5) receptors are expressed by neurons of the corticospinal and rubrospinal projections, and by intrinsic neurons of the spinal cord, both before and after spinal cord injury. Neutralization of netrin-1 in myelin prepared from adult rat spinal cord using UNC5 receptor bodies increases neurite outgrowth from UNC5-expressing spinal motor neurons in vitro. Furthermore, axon regeneration is inhibited in a netrin-1-enriched zone, devoid of other myelin-associated inhibitors, within spinal cord lesion sites in vivo. We conclude that netrin-1 is a novel oligodendrocyte-associated inhibitor that can contribute to axonal growth failure after adult spinal cord injury.

Netrin-1 is a novel myelin-associated inhibitor to axon growth. Publishing Authors By Initials

K Löw,M Culbertson,F Bradke,M Tessier-Lavigne,MH Tuszynski,K Löw,M Culbertson,F Bradke,M Tessier-Lavigne,MH Tuszynski,

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Netrin-1 is a novel myelin-associated inhibitor to axon growth. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuroscience : the official journal

VOLUME: 28

Page Numbers: 1099-108

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 30

MONTH: Jan

YEAR: 2008

Netrin-1 is a novel myelin-associated inhibitor to axon growth. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

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Grant and Affiliation Information for Netrin-1 is a novel myelin-associated inhibitor to axon growth.

AFFILIATION: Department of Neurosciences, University of California-San Diego, La Jolla, California 92093, USA. kloew@ucsd.edu

Country: United States

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MEDLINETA: J Neurosci

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