Nested case-control study of autoimmune disease in an asbestos-exposed population.

Nested case-control study of autoimmune disease in an asbestos-exposed population. Research Abstract Details 

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Nested case-control study of autoimmune disease in an asbestos-exposed population. Abstract Text:

Curtis W Noonan,Jean C Pfau,Theodore C Larson,Michael R Spence,

OBJECTIVE: To explore the potential association between asbestos exposure and risk of autoimmune disease, we conducted a case-control study among a cohort of 7,307 current and former residents of Libby, Montana, a community with historical occupational and environmental exposure to asbestos-contaminated vermiculite. METHODS: Cases were defined as those who reported having one of three systemic autoimmune diseases (SAIDs): systemic lupus erythematosus, scleroderma, or rheumatoid arthritis (RA). Controls were randomly selected at a 3:1 ratio from among the remaining 6,813 screening participants using frequency-matched age and sex groupings. RESULTS: The odds ratios (ORs) and 95% confidence intervals (CIs) for SAIDs among those >or=65 years of age who had worked for the vermiculite mining company were 2.14 (95% CI, 0.90-5.10) for all SAIDs and 3.23 (95% CI, 1.31-7.96) for RA. In this age group, exposure to asbestos while in the military was also an independent risk factor, resulting in a tripling in risk. Other measures of occupational exposure to vermiculite indicated 54% and 65% increased risk for SAIDs and RA, respectively. Those who had reported frequent contact with vermiculite through various exposure pathways also demonstrated elevated risk for SAIDs and RA. We found increasing risk estimates for SAIDs with increasing numbers of reported vermiculite exposure pathways (p<0.001). CONCLUSION: These preliminary findings support the hypothesis that asbestos exposure is associated with autoimmune disease. Refined measurements of asbestos exposure and SAID status among this cohort will help to further clarify the relationship between these variables.

Nested case-control study of autoimmune disease in an asbestos-exposed population. Publishing Authors By Initials

CW Noonan,JC Pfau,TC Larson,MR Spence,

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Nested case-control study of autoimmune disease in an asbestos-exposed population. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Environmental health perspectives

VOLUME: 114

Page Numbers: 1243-7

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ISSN: 0091-6765

DAY: 3

MONTH: Aug

YEAR: 2006

Nested case-control study of autoimmune disease in an asbestos-exposed population. Information

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LANGUAGE: eng

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AFFILIATION: Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, USA. curtis.noonan@umontana.edu

Country: United States

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MEDLINETA: Environ Health Perspect

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