Nephroblastoma overexpressed (nov) is a novel bone morphogenetic protein antagonist.

Nephroblastoma overexpressed (nov) is a novel bone morphogenetic protein antagonist. Research Abstract Details 

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Nephroblastoma overexpressed (nov) is a novel bone morphogenetic protein antagonist. Abstract Text:

Ernesto Canalis,Ernesto Canalis,Ernesto Canalis,

Nephroblastoma overexpressed (Nov), a member of the CCN family of proteins, is expressed by osteoblasts and its transcription is regulated by transforming growth factor (TGF)-beta and bone morphogenetic proteins (BMP). CCN proteins can interact with TGF-beta, BMPs, and Wnt. We explored the function of Nov in skeletal cells, in vitro and in vivo. Constitutive overexpression of Nov in cells of the osteoblastic lineage impaired osteoblastic differentiation, opposed the biological effects of BMP-2 and Wnt 3 and impaired BMP-2 and Wnt signaling, indicating that Nov has BMP-2 antagonistic activity. Transgenic mice overexpressing Nov under the control of the osteocalcin promoter exhibited osteopenia secondary to decreased bone formation, confirming the effects in vitro. GST pulldown experiments demonstrated direct Nov-BMP interactions. In conclusion, Nov has BMP antagonistic properties and inhibits osteoblastogenesis and osteoblastic function.

Nephroblastoma overexpressed (nov) is a novel bone morphogenetic protein antagonist. Publishing Authors By Initials

E Canalis,E Canalis,E Canalis,

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Nephroblastoma overexpressed (nov) is a novel bone morphogenetic protein antagonist. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1116

Page Numbers: 50-8

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 17

MONTH: Dec

YEAR: 2007

Nephroblastoma overexpressed (nov) is a novel bone morphogenetic protein antagonist. Information

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LANGUAGE: eng

NlmUniqueID: 7506858

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Grant and Affiliation Information for Nephroblastoma overexpressed (nov) is a novel bone morphogenetic protein antagonist.

AFFILIATION: Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105-1299. ecanalis@stfranciscare.org.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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