Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression.

Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Research Abstract Details 

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Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Abstract Text:

BACKGROUND: Opticin is a recently discovered glycoprotein present predominantly in the vitreous humour. It is synthesised and secreted by the ciliary body epithelium (CBE) from the initiation of CBE development in the embryo, and production continues throughout life. AIM: To determine whether a variety of ciliary body tumours synthesise opticin to characterise further its role in ciliary body health and disease. METHODS: Immunohistochemistry was used to determine the distribution of opticin in normal human CBE, and in hyperplastic and neoplastic CBE lesions. RESULTS: Opticin was immunolocalised to the basal cell surface and basement membrane material of the non-pigmented CBE in nine donor eyes as well as four hyperplastic lesions of the CBE (Fuchs's adenoma). By contrast, none of eight neoplastic lesions (two adenoma and six adenocarcinoma) of CBE stained for opticin. CONCLUSION: The present series supports the theory that opticin is produced by the non-pigmented CBE throughout adult life. Loss of opticin expression by this tissue is associated with and could contribute towards neoplastic transformation.

Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Publishing Authors By Initials

For similar neoplasms: neoplasms by site: eye neoplasms: uveal neoplasms research abstracts see: neoplasms: neoplasms by site: eye neoplasms: uveal neoplasms research

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Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 91

Page Numbers: 230-2

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 27

MONTH: 09

YEAR: 2006

Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Keywords Mesh Terms:

KEYWORDS: Uveal Neoplasms

MESH TERMS: metabolism

Chemical & Substance for Abstract: Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Information

Substance Name: Proteoglycans

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Grant and Affiliation Information for Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression.

AFFILIATION: Unit of Ophthalmology, Department of Medicine, University Clinical Departments, Duncan Building, Daulby Street, Liverpool L69 3GA, UK. dave@assheton.org

Country: England

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MEDLINETA: Br J Ophthalmol

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