Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone.

Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Research Abstract Details 

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Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Abstract Text:

Vinod Pullarkat,Victoria Bedell,Young Kim,Ravi Bhatia,Ryotaro Nakamura,Stephen Forman,Jiyao Sun,David Senitzer,Marilyn L Slovak,

In systemic mastocytosis with associated clonal, hematological non-mast cell lineage disease (SM-AHNMD), mast cell infiltration of the bone marrow coexists with a hematologic neoplasm, usually of myeloid origin. Activating KIT gene mutations are universally present in these neoplastic mast cells. When SM is associated with AML, the leukemic cells commonly carry the t(8;21)(q22;q22) core binding factor translocation. The precise relationship between neoplastic mast cells and the leukemic clone has remained unclear. By target FISH analysis, we demonstrate t(8;21) in the bone marrow mast cells of a patient with systemic mastocytosis associated with t(8;21) AML, thus, proving the origin of these neoplastic mast cells from the leukemic clone. We also show that after successful allogeneic hematopoietic stem cell transplantation, these neoplastic bone marrow mast cells can persist without adverse consequences and gradually decline with time.

Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Publishing Authors By Initials

V Pullarkat,V Bedell,Y Kim,R Bhatia,R Nakamura,S Forman,J Sun,D Senitzer,ML Slovak,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: proto-oncogene proteins c-kit research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: proto-oncogene proteins c-kit research

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Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Leukemia research

VOLUME: 31

Page Numbers: 261-5

Journal Abbreviation: Leuk. Res.

ISSN: 0145-2126

DAY: 28

MONTH: 07

YEAR: 2006

Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Information

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LANGUAGE: eng

NlmUniqueID: 7706787

Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Keywords Mesh Terms:

KEYWORDS: Proto-Oncogene Proteins c-kit

MESH TERMS: genetics

Chemical & Substance for Abstract: Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Information

Substance Name: Proto-Oncogene Proteins c-kit

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone.

AFFILIATION: Division of Hematology and Hematopoietic Cell Transplantation, Department of Cytogenetics, Division of Pathology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, United States. vpullarkat@coh.org

Country: England

AGENCY: United States NCI

GRANT: P01 CA030206-24

ACRONYM: CA

MEDLINETA: Leuk Res

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