Neonatal lung and airway injury: a role for neurotrophins.

Neonatal lung and airway injury: a role for neurotrophins. Research Abstract Details 

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Neonatal lung and airway injury: a role for neurotrophins. Abstract Text:

Qin Yao,Syed I Zaidi,Musa A Haxhiu,Richard J Martin,

Maintenance of patency in distal airways is essential for gas exchange in neonatal life, and its disruption may have long-lasting effects on respiratory function. However, neural mechanisms that regulate caliber of intrapulmonary airways during early postnatal life, and their disruption by hyperoxic exposure, have not been well characterized. We have previously shown that cholinergically mediated airway contractile responses in rat pups are upregulated after hyperoxic exposure, and that increased expression of neuropeptides, such as substance P, may be contributory. More recently, we have documented impairment of neurally mediated airway relaxation in response to hyperoxic stress associated with loss of nitric oxide and prostaglandin-induced airway relaxation as well as inhibition of long chain myosin phosphatase. Our most recent data demonstrate significantly enhanced expression of the neurotrophin, brain-derived neurotrophic factor (BDNF) and its high affinity specific tyrosine kinase B (TrkB) receptor in hyperoxia-exposed airway smooth muscle. The existence of a BDNF-TrkB receptor autocrine and paracrine loops in the airways provides a basis for understanding local regulatory mechanisms of airway homeostasis. A mechanistic role for BDNF-TrkB signaling in hyperoxia-induced airway hyperreactivity in early postnatal life could serve to modulate both afferent and efferent neural pathways that result in enhanced contractile responses of immature airways exposed to hyperoxic stress. Greater insight into these neural pathways may lead to future preventive strategies for preterm infants surviving neonatal intensive care and developing chronic lung disease.

Neonatal lung and airway injury: a role for neurotrophins. Publishing Authors By Initials

Q Yao,SI Zaidi,MA Haxhiu,RJ Martin,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

PUBMED ID PMID:

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Neonatal lung and airway injury: a role for neurotrophins. Journal Published:

PUBLICATION TYPE: Review

Journal: Seminars in perinatology

VOLUME: 30

Page Numbers: 156-62

Journal Abbreviation: Semin. Perinatol.

ISSN: 0146-0005

DAY: 3

MONTH: Jun

YEAR: 2006

Neonatal lung and airway injury: a role for neurotrophins. Information

Number of References: 50

LANGUAGE: eng

NlmUniqueID: 7801132

Neonatal lung and airway injury: a role for neurotrophins. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: metabolism

Chemical & Substance for Abstract: Neonatal lung and airway injury: a role for neurotrophins. Information

Substance Name: Nerve Growth Factors

Registry Number: 0

Grant and Affiliation Information for Neonatal lung and airway injury: a role for neurotrophins.

AFFILIATION: Department of Pediatrics, Case Western Reserve University School of Medicine, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 56470

ACRONYM: HL

MEDLINETA: Semin Perinatol

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