Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons.

Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons. Research Abstract Details 

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Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons. Abstract Text:

C B Boylan,K Davis,C A Bennett-Clarke,R W Rhoades,

Previous studies in adult animals have suggested that the peptides galanin and neuropeptide Y (NPY) may be upregulated in the same primary afferent neurons after peripheral axotomy. The present study was undertaken to determine whether such upregulation occurred in vibrissae-related primary afferent neurons and their axons after damage to the infraorbital nerve [ION; the trigeminal (V) branch that innervates the vibrissae follicles]. Double-labelling experiments demonstrated that approximately 75% of axotomized V ganglion cells and the central arbors of vibrissae-related primary afferents expressed both galanin and NPY after perinatal, but not adult, nerve damage. However, additional experiments demonstrated that the sensitive periods for lesion-induced upregulation of the two peptides and the period over which they were expressed after neonatal ION transection differed substantially. Staining for both peptides was increased after ION damage on P-0 through P-14, but only galanin staining was increased in vibrissae-related primary afferents after lesions on P-21. Galanin expression was elevated in vibrissae-related primary afferents in rats killed 3, 8, and 15 days after neonatal ION transection, while increased NPY was observed at only the middle time point. The lesion-induced increases in galanin and NPY in vibrissae-related ION primary afferents suggest that these peptides may modulate central V reorganization after such damage.

Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons. Publishing Authors By Initials

CB Boylan,K Davis,CA Bennett-Clarke,RW Rhoades,

For similar nervous system: peripheral nervous system: peripheral nerves: cranial nerves: trigeminal nerve research abstracts see: nervous system: peripheral nervous system: peripheral nerves: cranial nerves: trigeminal nerve research

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Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 112

Page Numbers: 475-84

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: Dec

YEAR: 1996

Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons. Keywords Mesh Terms:

KEYWORDS: Trigeminal Nerve

MESH TERMS: injuries

Chemical & Substance for Abstract: Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons. Information

Substance Name: Galanin

Registry Number: 88813-36-9

Grant and Affiliation Information for Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons.

AFFILIATION: Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo 43699, USA.

Country: GERMANY

AGENCY: United States NINDS

GRANT: NS 28888

ACRONYM: NS

MEDLINETA: Exp Brain Res

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