Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey.

Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Research Abstract Details 

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Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Abstract Text:

Jeppe Romme Christensen,Karen Bonde Larsen,Sarah H Lisanby,Jason Scalia,Victoria Arango,Andrew J Dwork,Bente Pakkenberg,

The rhesus monkey is widely used as an experimental animal model in the study of brain function and disease. While previous quantitative studies have provided knowledge of regional numbers, little is known of the total neocortical neuron and glial cell numbers in this species. The aim of this study is to establish quantitative norms. We use the optical fractionator and Cavalieri principle to examine the right hemisphere of eight young rhesus monkeys taken from the control group of an ongoing study. Applying these methods to agar-embedded and vibratome-sectioned tissue, we generate estimates of cell numbers and regional volumes of neocortical and hippocampal regions with coefficients of variance (CV) around 10%. The mean unilateral neocortical neuron number is 1.35 x 10(9) (CV +/- 0.10) and the mean unilateral neocortical glial cell number is 0.78 x 10(9) (CV +/- 0.17). Mean unilateral neocortical volume is found to be 8.5 (CV +/- 0.10) cm(3) after processing, or 19 cm(3) when correcting for shrinkage. The neuron/glia ratio is 1.77. The neurons are distributed with 18% in the frontal cortex, 57% in the temporal and parietal cortices, and 25% in the occipital cortex. In the hippocampal subregions, we found unilateral neuron number of 1.72 x 10(6) (CV +/- 0.13) and glial number of 2.25 x 10(6) (CV +/- 0.17) in CA1, and 0.80 x 10(6) (CV +/- 0.27) neurons and 1.05 x 10(6) (CV +/- 0.26) glial cells in CA2-3. Comparisons with related studies show quantitative variation, but also variations in methods and applications. The results are phylogenetically consistent, apart from the neuron/glia ratio, which is remarkably higher than what is found in other species.

Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Publishing Authors By Initials

JR Christensen,KB Larsen,SH Lisanby,J Scalia,V Arango,AJ Dwork,B Pakkenberg,

For similar natural sciences: weights and measures: reference values research abstracts see: natural sciences: weights and measures: reference values research

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Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anatomical record (Hoboken, N.J. : 2007)

VOLUME: 290

Page Numbers: 330-40

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ISSN: 1932-8486

DAY: 3

MONTH: Mar

YEAR: 2007

Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Information

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LANGUAGE: eng

NlmUniqueID: 101292775

Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Keywords Mesh Terms:

KEYWORDS: Reference Values

MESH TERMS: cytology

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Grant and Affiliation Information for Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey.

AFFILIATION: Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark. jepperomme@get2net.dk

Country: United States

AGENCY: United States NIMH

GRANT: MH60884

ACRONYM: MH

MEDLINETA: Anat Rec (Hoboken)

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