Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma.

Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma. Research Abstract Details 

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Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma. Abstract Text:

T Mori,K Hosokawa,Y Kinoshita,A Watanabe,H Honjo,T Mori,K Hosokawa,Y Kinoshita,A Watanabe,H Honjo,T Mori,K Hosokawa,Y Kinoshita,A Watanabe,H Honjo,

The efficacy and toxicity of neoadjuvant carboplatin and paclitaxel administered on a weekly schedule for locally advanced cervical carcinoma were evaluated. Thirty patients staged as IB2-IVA according to the FIGO were treated with carboplatin (AUC 2; an area under the time-concentration of 2 mg*min/ml based on creatinine clearance) and paclitaxel (60 mg/m(2)) intravenously, every week for six cycles. A type III radical hysterectomy was then undertaken. Thirty patients were enrolled in this study. An objective response was recorded in 26 patients (87%, 95% CI 70-95%). Progressive disease was not observed. Grade 3 neutropenia was observed in only two patients (7%), and grade 1 or 2 neuropathy was seen in six patients (20%). The combination of carboplatin and paclitaxel given in weekly schedule for advanced cervical carcinoma was highly active, permitting a high rate of subsequent surgical resectability. It was well tolerated. This regimen may provide improved outcomes with minimal toxicity.

Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma. Publishing Authors By Initials

T Mori,K Hosokawa,Y Kinoshita,A Watanabe,H Honjo,T Mori,K Hosokawa,Y Kinoshita,A Watanabe,H Honjo,T Mori,K Hosokawa,Y Kinoshita,A Watanabe,H Honjo,

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PUBMED ID PMID:

MEDLINE DATE: 2008 Jan-Feb

Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of gynecological cancer : of

VOLUME: 18

Page Numbers: 85-9

Journal Abbreviation: Int. J. Gynecol. Cancer

ISSN: 1048-891X

DAY: 22

MONTH: 06

YEAR: 2007

Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 9111626

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AFFILIATION: Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Country: United States

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MEDLINETA: Int J Gynecol Cancer

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