Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice.

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice. Abstract Text:

Anthony Fyles,Geoffrey Wood,Ming Li,Armen S Manoukian,Katrina Gowing,Rama Khokha,William Chapman,Ming-Sound Tsao,Anthony Fyles,Geoffrey Wood,Ming Li,Armen S Manoukian,Katrina Gowing,Rama Khokha,William Chapman,Ming-Sound Tsao,

OBJECTIVE: Hormonal therapy for type I (endometrioid) endometrial carcinoma is employed as both a conservative treatment option and for advanced or recurrent disease, but outcome is often poor. Our objective was to test whether ovariectomy, or ovariectomy followed by progestin treatment prevents the development of endometrial lesions in the pten+/- mouse model of endometrial cancer. METHODS: pten+/- mice underwent ovariectomy or sham surgery at 6 or 12 weeks of age. Groups of mice were sacrificed at 24, 30 or 40 weeks. Different cohorts of pten+/- mice were ovariectomized at 6 or 12 weeks of age, followed by medroxyprogesterone acetate (MPA) treatment at low or high-dose (25 or 200 mg total dose, respectively) over 21 days, beginning at 30 weeks of age. Uteri from all mice were examined by routine histology and immunohistochemistry. RESULTS: Without MPA treatment, 16 of 18 ovariectomized animals developed endometrial neoplasms (atypical hyperplasia or adenocarcinoma), as did all 9 sham surgery mice. Immunophenotypes for all tumors were consistent with activation of the phosphoinositidyl-3-kinase (PI3K) pathway, showing staining for phosphorylated PKB/Akt, phosphorylated S6 ribosomal protein and phosphorylated GSK3alpha/beta. All 10 mice treated with either low or high-dose MPA developed endometrial tumors, again with persistent activation of the PI3K signaling pathway. CONCLUSIONS: Development of endometrial neoplasms and constitutive activation of the PI3K pathway in pten+/- mice is not affected by hormonal ablation or by progestin treatment. Loss of PTEN expression is common during human endometrial cancer development, and this may render lesions resistant to the effects of hormonal manipulation leading to treatment failure.

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice. Publishing Authors By Initials

A Fyles,G Wood,M Li,AS Manoukian,K Gowing,R Khokha,W Chapman,MS Tsao,A Fyles,G Wood,M Li,AS Manoukian,K Gowing,R Khokha,W Chapman,MS Tsao,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gynecologic oncology

VOLUME: 108

Page Numbers: 395-401

Journal Abbreviation: Gynecol. Oncol.

ISSN: 1095-6859

DAY: 28

MONTH: 11

YEAR: 2007

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 365304

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice.

AFFILIATION: Department of Radiation Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada. anthony.fyles@rmp.uhn.on.ca

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Gynecol Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice Related Publications

• ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.
• Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.
• Chromobacterium violaceum infection in Taiwan: a case report and literature review.
• Concanavalin A protects mice from a lethal inoculation of intragastric Klebsiella pneumoniae and reduces the induced liver damage.
• Current topics in human SLE genetics.
• Dosage Prediction via Estimation of Shell Thickness and Concentration of Drug Carrier with Microbubbles.
• Effectiveness of Massage Therapy for Chronic, Non-malignant Pain: A Review.
• Effects of electrolytes on the molecular weight of tropomyosin.
• Effects of geometrical characteristics of surface roughness on droplet wetting.
• Efficacy of selected complementary and alternative medicine interventions for chronic pain.
• Eighth international mesothelioma interest group.
• Extramedullary plasmacytoma (EMP): Report of a case manifested as a mediastinal mass and multiple pulmonary nodules and review of literature.
• From Zanius to ADMA: ADMA - a new ''adipocytokine'' and its potential role in metabolic syndrome.
• Genetics of melanoma tumorigenesis.
• Genodermatoses with cutaneous tumors and internal malignancies.
• Gly392Cys missense mutation in the A2 domain of factor V causing severe factor V deficiency: molecular characterization by expression of the recombinant protein.
• HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
• Latent membrane protein-1 of Epstein-Barr virus inhibits cell growth and induces sensitivity to cisplatin in nasopharyngeal carcinoma cells.
• Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice.
• Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse.
• Outcome and hospital cost for infants weighing less than 500 grams: a tertiary centre experience in Taiwan.
• Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells.
• Photoreceptor protection against light damage by AAV-mediated overexpression of heme oxygenase-1.
• Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma.
• Quality of life in patients with brain metastases treated with a palliative course of whole-brain radiotherapy.
• Quality of sleep and quality of life in caregivers of breast cancer patient.
• Specialized color modules in macaque extrastriate cortex.
• Studies in spaced and massed learning; meaningfulness of material and distribution of practice.
• The great fortune of misfortune: An unusual cause of gastrointestinal haemorrhage.
• Three-gene prognostic classifier for early-stage non small-cell lung cancer.