Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide.

Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide. Research Abstract Details 

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Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide. Abstract Text:

Elizabeth A Stohl,H Steven Seifert,Elizabeth A Stohl,H Steven Seifert,

The strict human pathogen Neisseria gonorrhoeae is exposed to oxidative damage during infection. N. gonorrhoeae has many defenses that have been demonstrated to counteract oxidative damage. However, recN is the only DNA repair and recombination gene upregulated in response to hydrogen peroxide (H(2)O(2)) by microarray analysis and subsequently shown to be important for oxidative damage protection. We therefore tested the importance of RecA and DNA recombination and repair enzymes in conferring resistance to H(2)O(2) damage. recA mutants, as well as RecBCD (recB, recC, and recD) and RecF-like pathway mutants (recJ, recO, and recQ), all showed decreased resistance to H(2)O(2). Holliday junction processing mutants (ruvA, ruvC, and recG) showed decreased resistance to H(2)O(2) resistance as well. Finally, we show that RecA protein levels did not increase as a result of H(2)O(2) treatment. We propose that RecA, recombinational DNA repair, and branch migration are all important for H(2)O(2) resistance in N. gonorrhoeae but that constitutive levels of these enzymes are sufficient for providing protection against oxidative damage by H(2)O(2).

Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide. Publishing Authors By Initials

EA Stohl,HS Seifert,EA Stohl,HS Seifert,

For similar enzymes and coenzymes: enzymes: recombinases research abstracts see: enzymes and coenzymes: enzymes: recombinases research

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Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of bacteriology

VOLUME: 188

Page Numbers: 7645-51

Journal Abbreviation: J. Bacteriol.

ISSN: 0021-9193

DAY: 25

MONTH: 08

YEAR: 2006

Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985120

Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide. Keywords Mesh Terms:

KEYWORDS: Recombinases

MESH TERMS: physiology

Chemical & Substance for Abstract: Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide. Information

Substance Name: DNA Repair Enzymes

Registry Number: EC 6.5.1.-

Grant and Affiliation Information for Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide.

AFFILIATION: Northwestern University, Feinberg School of Medicine, 303 E. Chicago Ave., Chicago, IL 60611, USA. e-stohl@northwestern.edu

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI044239

ACRONYM: AI

MEDLINETA: J Bacteriol

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