Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Research Abstract Details 

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Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Abstract Text:

Y Yoshida,S Tanaka,H Umemori,O Minowa,M Usui,N Ikematsu,E Hosoda,T Imamura,J Kuno,T Yamashita,K Miyazono,M Noda,T Noda,T Yamamoto,

Bone morphogenetic protein (BMP) controls osteoblast proliferation and differentiation through Smad proteins. Here we show that Tob, a member of the emerging family of antiproliferative proteins, is a negative regulator of BMP/Smad signaling in osteoblasts. Mice carrying a targeted deletion of the tob gene have a greater bone mass resulting from increased numbers of osteoblasts. Orthotopic bone formation in response to BMP2 is elevated in tob-deficient mice. Overproduction of Tob represses BMP2-induced, Smad-mediated transcriptional activation. Finally, Tob associates with receptor-regulated Smads (Smad1, 5, and 8) and colocalizes with these Smads in the nuclear bodies upon BMP2 stimulation. The results indicate that Tob negatively regulates osteoblast proliferation and differentiation by suppressing the activity of the receptor-regulated Smad proteins.

Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Publishing Authors By Initials

Y Yoshida,S Tanaka,H Umemori,O Minowa,M Usui,N Ikematsu,E Hosoda,T Imamura,J Kuno,T Yamashita,K Miyazono,M Noda,T Noda,T Yamamoto,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 103

Page Numbers: 1085-97

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 22

MONTH: Dec

YEAR: 2000

Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Information

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LANGUAGE: eng

NlmUniqueID: 413066

Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Information

Substance Name: bone morphogenetic protein 7

Registry Number: 0

Grant and Affiliation Information for Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

AFFILIATION: Department of Oncology, The Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

Country: United States

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MEDLINETA: Cell

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