Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants.

Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Research Abstract Details 

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Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Abstract Text:

Ezra R Lowe,Andrew C Everett,Miranda Lau,Anwar Y Dunbar,David Michener,Yoichi Osawa,

NO-synthase (NOS) is a heme-containing enzyme that catalyzes the oxidation of L-arginine to nitric oxide, an important cellular signaling molecule. Recently, it was found that aqueous extracts of tobacco cigarettes cause the inactivation of the neuronal isoform of NOS (nNOS) and that this may explain some of the toxicological effects of smoking. Although the exact identity of the chemical inactivator(s) is not known, we wondered if extracts prepared from other plants, including those closely related to tobacco, Nicotiana tabacum (Solanaceae), would similarly inactivate nNOS. We examined 33 plants, representing diverse members of the plant kingdom ranging from whisk fern, Psilotum nudum (Psilotaceae) to tobacco and discovered 18 plants that contain a chemical inactivator(s) of nNOS. Of these plants, 16 are members of the core asterids flowering plant group. Of these asterids, 6 are members of the Solanaceae family, of which tobacco is a member. Based on the phylogenetic relationship of the plants, it is possible that the same chemical or related chemical inactivator(s) exist. This, in turn, may help elucidate the structure of the chemical(s), as well as provide a source of a potentially novel inactivator of nNOS. The alkaloid nicotine can be excluded as putative nNOS inhibitor.

Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Publishing Authors By Initials

ER Lowe,AC Everett,M Lau,AY Dunbar,D Michener,Y Osawa,

For similar plants: plant families and groups: angiosperms: solanaceae: tobacco research abstracts see: plants: plant families and groups: angiosperms: solanaceae: tobacco research

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Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Phytomedicine : international journal of phytother

VOLUME: 14

Page Numbers: 344-52

Journal Abbreviation:

ISSN: 0944-7113

DAY: 3

MONTH: 11

YEAR: 2006

Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9438794

Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Keywords Mesh Terms:

KEYWORDS: Tobacco

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Information

Substance Name: Nitric Oxide Synthase Type I

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants.

AFFILIATION: Department of Pharmacology, The University of Michigan Medical School, 1301 Medical Science Research Building III, Ann Arbor, MI 48109-0632, USA.

Country: Germany

AGENCY: United States NIGMS

GRANT: GM07767

ACRONYM: GM

MEDLINETA: Phytomedicine

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