Naturally occurring compounds affect glutamatergic neurotransmission in rat brain.

Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. Research Abstract Details 

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Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. Abstract Text:

Lucia Helena Martini,Fernanda Jung,Felix Antunes Soares,Liane Nanci Rotta,Deusa Aparecida Vendite,Marcos Emilio dos Santos Frizzo,Rosendo A Yunes, Calixto,Susana Wofchuk,Diogo O Souza,Lucia Helena Martini,Fernanda Jung,Felix Antunes Soares,Liane Nanci Rotta,Deusa Aparecida Vendite,Marcos Emilio dos Santos Frizzo,Rosendo A Yunes, Calixto,Susana Wofchuk,Diogo O Souza,

Natural products, including those derived from plants, have largely contributed to the development of therapeutic drugs. Glutamate is the main excitatory neurotransmitter in the central nervous system and it is also considered a nociceptive neurotransmitter, by acting on peripheral nervous system. For this reason, in this study we investigated the effects of the hydroalcoholic extracts from Drymis winteri (polygodial and drimanial), Phyllanthus (rutin and quercetine), Jathopha elliptica (jatrophone), Hedyosmum brasiliense (13HDS), Ocotea suaveolens (Tormentic acid), Protium kleinii (alphabeta-amyrin), Citrus paradise (naringin), soybean (genistein) and Crataeva nurvala (lupeol), described as having antinociceptive effects, on glutamatergic transmission parameters, such as [(3)H]glutamate binding, [(3)H]glutamate uptake by synaptic vesicles and astrocyte cultures, and synaptosomal [(3)H]glutamate release. All the glutamatergic parameters were affected by one or more of these compounds. Specifically, drimanial and polygodial presented more broad and profound effects, requiring more investigation on their mechanisms. The putative central side effects of these compounds, via the glutamatergic system, are discussed.

Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. Publishing Authors By Initials

LH Martini,F Jung,FA Soares,LN Rotta,DA Vendite,ME Frizzo,RA Yunes,JB Calixto,S Wofchuk,DO Souza,LH Martini,F Jung,FA Soares,LN Rotta,DA Vendite,ME Frizzo,RA Yunes,JB Calixto,S Wofchuk,DO Souza,

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Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurochemical research

VOLUME: 32

Page Numbers: 1950-6

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 19

MONTH: 06

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7613461

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AFFILIATION: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS 90035-003, Brazil.

Country: United States

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MEDLINETA: Neurochem Res

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