[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review]

[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review] Research Abstract Details 

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[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review] Abstract Text:

Feng-kui Zhang,Hui-jun Wang,Yu-hong Wu,Shu-xu Dong,Hong-qiang Li,Dong-lin Yang,Hui-shu Chen,Yu-lin Chu,

OBJECTIVE: To identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia. METHODS: The characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures. RESULTS: A 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer. Atypical lymphoid cells surrounded the dermal vessels with a CD3(+), CD8(+), CD4(-), CD5(-), CD10(-), CD19(-), CD57(-), CD56(+), perforin(+), granzyme B(+) immunophenotype and rearranged T-cell receptor-gamma gene implicated natural killer-like T cell origin. She was treated with prednisone and for several months. Then the patient developed progressive spleen enlargement with overt leukemia, which led to her eventual death. CONCLUSIONS: Natural killer-like T-cell lymphoma/leukemia is a rare disease with distinctive clinical, histopathologic, and immuno phenotypic characteristics. Current treatment modalities are ineffective for most of the patients.

[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review] Publishing Authors By Initials

FK Zhang,HJ Wang,YH Wu,SX Dong,HQ Li,DL Yang,HS Chen,YL Chu,

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[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 27

Page Numbers: 226-30

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ISSN: 0253-2727

DAY: 31

MONTH: Apr

YEAR: 2006

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LANGUAGE: chi

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AFFILIATION: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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