Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells.

Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Research Abstract Details 

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Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Abstract Text:

Ting Zhang,Yuan Li,Yan-Jian Wang,Xu Wang,Mike Young,Steven D Douglas,Wen-Zhe Ho,

Natural killer (NK) cells are a crucial component of the host innate immune system. We investigated the noncytolytic anti-human immunodeficiency virus (HIV) activity of NK cells in chronically HIV-infected immune cells. Supernatants collected from NK cell cultures (both primary NK cells and NK cell lines, YTS and NK 92) inhibited HIV activation in peripheral blood mononuclear cells (PBMCs) from HIV-infected subjects. NK supernatants (NK SN) also suppressed tumor necrosis factor (TNF)-alpha-induced HIV activation in chronically infected cell lines (U1 and ACH-2 cells). The antibody to interferon (IFN)-gamma blocked NK SN-mediated anti-HIV effect, while the antibodies to CC-chemokines had no impact on NK SN-mediated HIV inhibition in U1 and ACH-2 cells. Investigation of mechanism(s) responsible for the NK action showed that NK SN inhibited TNF-alpha-mediated activation of HIV-long-terminal repeat (LTR), and upregulated the expression of signal transducer and activator of transcription (STAT)-1 and phosphorylated P38 mitogen-activated protein kinase (MAPK). The P38 MAPK inhibitor (SB 203580) blocked NK SN-mediated HIV inhibition. These data provide compelling evidence that NK cells have a critical role in controlling HIV activation in the reservoirs.

Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Publishing Authors By Initials

T Zhang,Y Li,YJ Wang,X Wang,M Young,SD Douglas,WZ Ho,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research

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Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Antiviral research

VOLUME: 73

Page Numbers: 132-9

Journal Abbreviation: Antiviral Res.

ISSN: 0166-3542

DAY: 12

MONTH: 09

YEAR: 2006

Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109699

Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Keywords Mesh Terms:

KEYWORDS: p38 Mitogen-Activated Protein Kinases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Information

Substance Name: p38 Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells.

AFFILIATION: Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute of The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Country: Netherlands

AGENCY: United States NIMH

GRANT: P01-MH76388

ACRONYM: MH

MEDLINETA: Antiviral Res

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