Natural history of pain following herpes zoster.

Natural history of pain following herpes zoster. Research Abstract Details 

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Natural history of pain following herpes zoster. Abstract Text:

In a longitudinal observational study of 94 patients (39 M:55 F, mean age 69) at elevated risk for developing post herpetic neuralgia (PHN), the natural history of pain during the first 6 months after herpes zoster (HZ) rash onset was determined. Pain severity and impact were rated using pain-VAS, SF-MPQ, and MPI. Applying a definition of PHN of average daily pain >0/100 on the pain VAS during the last 48 h, 30 subjects had PHN at 6 months. These 30 subjects reported more pain and a higher SF-MPQ score (p<0.01) at study inclusion than the 64 subjects whose pain completely resolved by 6 months. At 6 months, mean daily pain in the PHN group was 11/100 (95% CI 5,16) and only nine of these subjects were still taking prescription medication for HZ pain. The rate of recovery (pain severity over time) was the same in the PHN and no-pain groups. At study inclusion, the SF-MPQ and MPI scores in our PHN group were similar to historical controls with chronic severe PHN enrolled in clinical trials, but by 6 months the scores in our PHN subjects were significantly lower than historic controls. Only two subjects met the more stringent criteria for 'clinically meaningful' PHN at 6 months (> or = 30/100 on the pain VAS). Defining PHN as average daily pain >0/100 at 6 months after rash onset appears to substantially overestimate the number of HZ patients negatively impacted by ongoing pain and disability.

Natural history of pain following herpes zoster. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Natural history of pain following herpes zoster. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pain

VOLUME: 128

Page Numbers: 148-56

Journal Abbreviation: Pain

ISSN: 1872-6623

DAY: 27

MONTH: 10

YEAR: 2006

Natural history of pain following herpes zoster. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7508686

Natural history of pain following herpes zoster. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: methods

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Grant and Affiliation Information for Natural history of pain following herpes zoster.

AFFILIATION: UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA 94115, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01 NS039521-04

ACRONYM: NS

MEDLINETA: Pain

REFSOURCE: Pain. 2007 Mar;128(1-2):189-90; author r

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