Natural expansion of the genetic code.

Natural expansion of the genetic code. Research Abstract Details 

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Natural expansion of the genetic code. Abstract Text:

Alexandre Ambrogelly,Sotiria Palioura,Dieter ,

At the time of its discovery four decades ago, the genetic code was viewed as the result of a "frozen accident." Our current knowledge of the translation process and of the detailed structure of its components highlights the roles of RNA structure (in mRNA and tRNA), RNA modification (in tRNA), and aminoacyl-tRNA synthetase diversity in the evolution of the genetic code. The diverse assortment of codon reassignments present in subcellular organelles and organisms of distinct lineages has 'thawed' the concept of a universal immutable code; it may not be accidental that out of more than 140 amino acids found in natural proteins, only two (selenocysteine and pyrrolysine) are known to have been added to the standard 20-member amino acid alphabet. The existence of phosphoseryl-tRNA (in the form of tRNACys and tRNASec) may presage the discovery of other cotranslationally inserted modified amino acids.

Natural expansion of the genetic code. Publishing Authors By Initials

A Ambrogelly,S Palioura,D ,

For similar organic chemicals: organoselenium compounds: selenocysteine research abstracts see: organic chemicals: organoselenium compounds: selenocysteine research

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Natural expansion of the genetic code. Journal Published:

PUBLICATION TYPE: Review

Journal: Nature chemical biology

VOLUME: 3

Page Numbers: 29-35

Journal Abbreviation: Nat. Chem. Biol.

ISSN: 1552-4450

DAY: 3

MONTH: Jan

YEAR: 2007

Natural expansion of the genetic code. Information

Number of References: 84

LANGUAGE: eng

NlmUniqueID: 101231976

Natural expansion of the genetic code. Keywords Mesh Terms:

KEYWORDS: Selenocysteine

MESH TERMS: genetics

Chemical & Substance for Abstract: Natural expansion of the genetic code. Information

Substance Name: Amino Acyl-tRNA Synthetases

Registry Number: EC 6.1.1.-

Grant and Affiliation Information for Natural expansion of the genetic code.

AFFILIATION: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM22854

ACRONYM: GM

MEDLINETA: Nat Chem Biol

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