Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species.

Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species. Research Abstract Details 

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Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species. Abstract Text:

Susanne B Schwedler,Peter J Kuhlencordt,P Padmapriya Ponnuswamy,Gencay Hatiboglu,Thomas Quaschning,Julian Widder,Christoph Wanner,Lawrence A Potempa,Jan Galle,Susanne B Schwedler,Peter J Kuhlencordt,P Padmapriya Ponnuswamy,Gencay Hatiboglu,Thomas Quaschning,Julian Widder,Christoph Wanner,Lawrence A Potempa,Jan Galle,

OBJECTIVE: In addition to being a risk marker for cardiovascular disease, recent data suggests that C-reactive protein (CRP) induces endothelial dysfunction and promotes oxidative stress. We evaluated the effects of two conformers of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) on vessel function and production of reactive oxygen species (ROS) in an in-vivo model of atherosclerosis. METHODS AND RESULTS: Female ApoE(-/-) mice, fed a "western-type" diet, were treated with either human nCRP or mCRP (2.5mg/kg s.c., weekly) or saline for 8 weeks. Endothelium-dependent and endothelium-independent vascular functions were assessed in isolated aortic rings under isometric conditions. Production of ROS in aortic rings was measured by electron spin resonance (ESR). Endothelium-dependent relaxation was impaired in nCRP-treated but not in mCRP-treated ApoE(-/-) mice. This impairment was reversed by preincubation with an inhibitor of inducible nitric oxide synthase (iNOS). Endothelium-independent relaxation, and iNOS and endothelial NOS (eNOS) protein expressions were similar among all groups. ESR experiments revealed lesser amounts of superoxide in the nCRP group as compared to the saline group, which is consistent with an increased transformation of NO to peroxynitrite. CONCLUSIONS: nCRP can facilitate cardiovascular disease through impairment of endothelium-dependent vasoreactivity, in a manner that involves increased iNOS activity and a potential for increased peroxynitrite formation.

Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species. Publishing Authors By Initials

SB Schwedler,PJ Kuhlencordt,PP Ponnuswamy,G Hatiboglu,T Quaschning,J Widder,C Wanner,LA Potempa,J Galle,SB Schwedler,PJ Kuhlencordt,PP Ponnuswamy,G Hatiboglu,T Quaschning,J Widder,C Wanner,LA Potempa,J Galle,

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Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Atherosclerosis

VOLUME: 195

Page Numbers: e76-84

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 31

MONTH: 07

YEAR: 2007

Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species. Information

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LANGUAGE: eng

NlmUniqueID: 242543

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Grant and Affiliation Information for Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species.

AFFILIATION: Department of Medicine I, University Hospital Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany. Pelleas@t-online.de

Country: Ireland

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MEDLINETA: Atherosclerosis

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