Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells.

Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Research Abstract Details 

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Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Abstract Text:

Nadine Wong Shi Kam,Theodore C Jessop,Paul A Wender,Hongjie Dai,

The interactions between various functionalized carbon nanotubes and several types of human cancer cells are explored. We have prepared modified nanotubes and have shown that these can be derivatized in a way that enables attachment of small molecules and of proteins, the latter through a novel noncovalent association. The functionalized carbon nanotubes enter nonadherent human cancer cells as well as adherent cell lines (CHO and 3T3) and by themselves are not toxic. While the fluoresceinated protein streptavidin (MW approximately 60 kD) by itself does not enter cells, it readily enters cells when complexed to a nanotube-biotin transporter and exhibits dose-dependent cytotoxicity. The uptake pathway is consistent with adsorption-mediated endocytosis. The use of carbon nanotubes as molecular transporters could be exploited for various cargos. The biocompatibility and unique physical, electrical, optical, and mechanical properties of nanotubes provide the basis for new classes of materials for drug, protein, and gene delivery applications.

Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Publishing Authors By Initials

NW Shi Kam,TC Jessop,PA Wender,H Dai,

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Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 6850-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 9

MONTH: Jun

YEAR: 2004

Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells.

AFFILIATION: Department of Chemistry, Stanford University, Stanford, California 94305, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA31845

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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