Nanotechnology applications in cancer.

Nanotechnology applications in cancer. Research Abstract Details 

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Nanotechnology applications in cancer. Abstract Text:

Shuming Nie,Yun Xing,Gloria J Kim,Jonathan W Simons,

Cancer nanotechnology is an interdisciplinary area of research in science, engineering, and medicine with broad applications for molecular imaging, molecular diagnosis, and targeted therapy. The basic rationale is that nanometer-sized particles, such as semiconductor quantum dots and iron oxide nanocrystals, have optical, magnetic, or structural properties that are not available from molecules or bulk solids. When linked with tumor targeting ligands such as monoclonal antibodies, peptides, or small molecules, these nanoparticles can be used to target tumor antigens (biomarkers) as well as tumor vasculatures with high affinity and specificity. In the mesoscopic size range of 5-100 nm diameter, nanoparticles also have large surface areas and functional groups for conjugating to multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic (e.g., anticancer) agents. Recent advances have led to bioaffinity nanoparticle probes for molecular and cellular imaging, targeted nanoparticle drugs for cancer therapy, and integrated nanodevices for early cancer detection and screening. These developments raise exciting opportunities for personalized oncology in which genetic and protein biomarkers are used to diagnose and treat cancer based on the molecular profiles of individual patients.

Nanotechnology applications in cancer. Publishing Authors By Initials

S Nie,Y Xing,GJ Kim,JW Simons,

For similar neoplasms research abstracts see: neoplasms research

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Nanotechnology applications in cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Annual review of biomedical engineering

VOLUME: 9

Page Numbers: 257-88

Journal Abbreviation:

ISSN: 1523-9829

DAY: 3

MONTH: 12

YEAR: 2007

Nanotechnology applications in cancer. Information

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LANGUAGE: eng

NlmUniqueID: 100883581

Nanotechnology applications in cancer. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: therapy

Chemical & Substance for Abstract: Nanotechnology applications in cancer. Information

Substance Name: Antineoplastic Agents

Registry Number: 0

Grant and Affiliation Information for Nanotechnology applications in cancer.

AFFILIATION: Department of Biomedical Engineering and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA. snie@emory.edu

Country: United States

AGENCY: United States NCI

GRANT: U54CA119338

ACRONYM: CA

MEDLINETA: Annu Rev Biomed Eng

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