Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression.

Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Research Abstract Details 

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Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Abstract Text:

Hyun Joon Kong,Susan Hsiong,David J Mooney,

It is hypothesized that the nanoscale organization of cell adhesion ligands in a synthetic ECM regulates nonviral gene delivery. This hypothesis was examined with pre-osteoblasts cultured on substrates which present varied density and spacing of synthetic adhesion ligands. The levels of gene transfer and expression were increased with the density of adhesion ligands, but decreased with the spacing of ligands, due to changes in the cell growth rate. This study provides a material-based control point on the nanometer scale for nonviral gene based therapies.

Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Publishing Authors By Initials

HJ Kong,S Hsiong,DJ Mooney,

For similar cells: connective tissue cells: osteoblasts research abstracts see: cells: connective tissue cells: osteoblasts research

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Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nano letters

VOLUME: 7

Page Numbers: 161-6

Journal Abbreviation: Nano Lett.

ISSN: 1530-6984

DAY: 3

MONTH: Jan

YEAR: 2007

Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101088070

Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Keywords Mesh Terms:

KEYWORDS: Osteoblasts

MESH TERMS: metabolism

Chemical & Substance for Abstract: Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Information

Substance Name: Ligands

Registry Number: 0

Grant and Affiliation Information for Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression.

AFFILIATION: Division of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts 02138, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: R 37 DE013033

ACRONYM: DE

MEDLINETA: Nano Lett

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