Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats.

Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats. Research Abstract Details 

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Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats. Abstract Text:

M Chen,R C Webb,R L Malvin,

These experiments were designed to determine if the opiate antagonist naloxone affects vascular sensitivity in 2K-1C hypertensive rats. Group 1 was 2K-1C hypertensive rats. Group 2 was 2K-1C rats given a naloxone infusion (100 micrograms/h) for 14 days. Group 3 received naloxone without clipping. Group 4 was untreated rats. At day 14 following clipping, systolic blood pressure was increased significantly in the 2K-1C rats. Those infused with naloxone showed a significant attenuation of the increase in blood pressure. Vascular responses to norepinephrine and KCl in the aortae from all groups were tested. Strips from untreated, 2K-1C rats were more sensitive to the contractile effects of norepinephrine than those from naloxone-treated, 2K-1C rats, and from both groups of normotensive rats. Contractile responsiveness to depolarizing concentrations of KCl were not different among the four groups. These data demonstrate that naloxone attenuates the development of renal hypertension and prevents the increase in vascular responsiveness to norepinephrine.

Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats. Publishing Authors By Initials

M Chen,RC Webb,RL Malvin,

For similar vasoconstriction research abstracts see: vasoconstriction research

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Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 12

Page Numbers: 1361-76

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1990

Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats. Keywords Mesh Terms:

KEYWORDS: Vasoconstriction

MESH TERMS: drug effects

Chemical & Substance for Abstract: Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats. Information

Substance Name: Norepinephrine

Registry Number: 51-41-2

Grant and Affiliation Information for Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats.

AFFILIATION: Department of Physiology, University of Michigan, Ann Arbor 48109.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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