Naive recirculating B cells mature simultaneously in the spleen and bone marrow.

Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Research Abstract Details 

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Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Abstract Text:

Annaiah Cariappa,Catharine Chase,Haoyuan Liu,Paul Russell,Shiv Pillai,

We have recently demonstrated that IgD(hi) B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgD(hi) naive recirculating B cells, but the existence of mutant mice that have selectively lost mature B cells in the bone marrow prompted an examination of B-cell maturation at this latter site. Following a single pulse of BrdU in intact mice, sequential labeling of more mature B-cell populations in the bone marrow suggested ongoing maturation at this site. Further evidence for B-cell maturation in the bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin alpha-deficient mice that lack all secondary lymphoid organs. In these mice, antibody-secreting cells recognizing multivalent antigens were also observed in the bone marrow following an intravenous microbial challenge. These data suggest that newly formed B cells mature into IgD(hi) B cells simultaneously in the spleen and the bone marrow and establish in a stringent manner that humoral immune responses can be initiated in situ in the bone marrow.

Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Publishing Authors By Initials

A Cariappa,C Chase,H Liu,P Russell,S Pillai,

For similar surgical procedures, operative: splenectomy research abstracts see: surgical procedures, operative: splenectomy research

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Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood

VOLUME: 109

Page Numbers: 2339-45

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 21

MONTH: 11

YEAR: 2006

Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Keywords Mesh Terms:

KEYWORDS: Splenectomy

MESH TERMS: metabolism

Chemical & Substance for Abstract: Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Information

Substance Name: Lymphotoxin-alpha

Registry Number: 0

Grant and Affiliation Information for Naive recirculating B cells mature simultaneously in the spleen and bone marrow.

AFFILIATION: Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL43340

ACRONYM: HL

MEDLINETA: Blood

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