Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Research Abstract Details 

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Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Abstract Text:

Cell-mediated immunity stems from the proliferation of naive T lymphocytes expressing T cell antigen receptors (TCRs) specific for foreign peptides bound to host major histocompatibility complex (MHC) molecules. Because of the tremendous diversity of the T cell repertoire, naive T cells specific for any one peptide:MHC complex (pMHC) are extremely rare. Thus, it is not known how many naive T cells of any given pMHC specificity exist in the body or how that number influences the immune response. By using soluble pMHC class II (pMHCII) tetramers and magnetic bead enrichment, we found that three different pMHCII-specific naive CD4(+) T cell populations vary in frequency from 20 to 200 cells per mouse. Moreover, naive population size predicted the size and TCR diversity of the primary CD4(+) T cell response after immunization with relevant peptide. Thus, variation in naive T cell frequencies can explain why some peptides are stronger immunogens than others.

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Publishing Authors By Initials

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Immunity

VOLUME: 27

Page Numbers: 203-13

Journal Abbreviation: Immunity

ISSN: 1074-7613

DAY: 16

MONTH: 08

YEAR: 2007

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9432918

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Information

Substance Name: Receptors, Antigen, T-Cell

Registry Number: 0

Grant and Affiliation Information for Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

AFFILIATION: Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Country: United States

AGENCY: United States NIAID

GRANT: F32 AI063793-02

ACRONYM: AI

MEDLINETA: Immunity

REFSOURCE: Immunity. 2007 Aug;27(2):179-80

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