NAD+ and NADH in ischemic brain injury.

NAD+ and NADH in ischemic brain injury. Research Abstract Details 

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NAD+ and NADH in ischemic brain injury. Abstract Text:

Weihai Ying,Weihai Ying,

NAD+ and NADH have been emerging as the common mediators of energy metabolism, mitochondrial functions, calcium homeostasis, aging and cell death. NAD+ and NADH can affect cell death by various mechanisms, such as influencing energy metabolism, mitochondrial permeability transition pores, and apoptosis-inducing factor. Because energy failure, calcium disregulation and cell death are the key components in the tissue damaging cascade initiated by cerebral ischemia, it is likely that NAD+ and NADH play significant roles in ischemic brain damage. Many studies, including the findings that poly(ADP-ribose) polymerase-1 mediates ischemic brain injury and that NAD+ administration can decrease ischemic brain damage, have suggested significant roles of NAD+ and NADH in the debilitating illness. However, there is still distinct insufficiency of the information regarding the roles of NAD+ and NADH in ischemic brain injury. Because increasing evidence has indicated critical functions of NAD+ and NADH in various biological processes, future studies on the roles of NAD+ and NADH in cerebral ischemia may expose essential mechanisms underlying ischemic brain injury and suggest novel therapeutic strategies for the illness.

NAD+ and NADH in ischemic brain injury. Publishing Authors By Initials

W Ying,W Ying,

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NAD+ and NADH in ischemic brain injury. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 13

Page Numbers: 1141-51

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 01

YEAR: 2008

NAD+ and NADH in ischemic brain injury. Information

Number of References: 135

LANGUAGE: eng

NlmUniqueID: 9709506

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Grant and Affiliation Information for NAD+ and NADH in ischemic brain injury.

AFFILIATION: Department of Neurology, San Francisco Veterans Affairs Medical Center and the University of California at San Francisco, San Francisco, CA 94121, USA. Weihai.Ying@ucsf.edu

Country: United States

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MEDLINETA: Front Biosci

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