Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling.

Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Abstract Text:

Christian Pott,Scott A Henderson,Joshua I Goldhaber,Kenneth D Philipson,

The Na+/Ca2+ exchanger (NCX) is the main Ca2+ extrusion mechanism of the cardiac myocyte. Nevertheless, cardiac-specific NCX knockout (KO) mice are viable to adulthood. We have identified two adaptations of excitation-contraction coupling (ECC) to the absence of NCX in these animals: (a) a reduction of the L-type Ca2+ current (I(Ca)) with an increase in ECC gain and (b) a shortening of the action potential (AP) to further limit Ca2+ influx. Both mechanisms contribute to Ca2+ homeostasis by reducing Ca2+ influx while maintaining contractility. These adaptations may comprise important feedback mechanisms by which cardiomyocytes may be able to limit Ca2+ influx in situations of compromised Ca2+ extrusion capacity.

Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Publishing Authors By Initials

C Pott,SA Henderson,JI Goldhaber,KD Philipson,

For similar proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: sodium-calcium exchanger research abstracts see: proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: sodium-calcium exchanger research

PUBMED ID PMID:

MEDLINE DATE:

Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of the New York Academy of Sciences

VOLUME: 1099

Page Numbers: 270-5

Journal Abbreviation:

ISSN: 0077-8923

DAY: 3

MONTH: Mar

YEAR: 2007

Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7506858

Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Keywords Mesh Terms:

KEYWORDS: Sodium-Calcium Exchanger

MESH TERMS: physiology

Chemical & Substance for Abstract: Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Information

Substance Name: Sodium-Calcium Exchanger

Registry Number: 0

Grant and Affiliation Information for Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling.

AFFILIATION: Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL70828

ACRONYM: HL

MEDLINETA: Ann N Y Acad Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling Related Publications

• 3 year simvastatin treatment and lens nuclear back scattering.
• Action potentials and insulin secretion: new insights into the role of Kv channels.
• Aortic valvular diseases studied by percutaneous thoracic aortography.
• Association between a recently isolated virus and an epidemic of upper respiratory disease in a day nursery.
• C-reactive protein in human colostrum.
• Cold climate genes and the prevalence of type 2 diabetes mellitus.
• Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart.
• Cost-effectiveness as a price control.
• Densitometric evaluation at quantitative microradiography.
• Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization.
• Homozygous overexpression of the Na+-Ca2+ exchanger in mice: evidence for increased transsarcolemmal Ca2+ fluxes.
• Intermolecular cross-linking of na(+)-ca(2+) exchanger proteins: evidence for dimer formation.
• Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.
• Localization of sarcolemmal proteins to lipid rafts in the myocardium.
• Microdensitometer system for microradiography.
• Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling.
• OC088: Is there a relationship between visualization of ectopic pregnancy on transvaginal scan and serum quantitative HCG?
• P35.01: Hitting the target but missing the point- the fatal flaw of ectopic pregnancy research.
• Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis.
• Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic -cell: a computational approach.
• Regulation of cardiac L-type Ca2+ current in Na+-Ca2+ exchanger knockout mice: functional coupling of the Ca2+ channel and the Na+-Ca2+ exchanger.
• Reliability of the drop test for the lacrimal drainage function.
• THE EARLY INTERACTION OF ANIMAL VIRUSES AND CELLS.
• Techniques for surgical retrieval of sperm prior to intra-cytoplasmic sperm injection (ICSI) for azoospermia.
• Techniques for surgical retrieval of sperm prior to intra-cytoplasmic sperm injection (ICSI) for azoospermia.
• The ontogeny of the shoot apex in dicotyledons.
• Treatment of post-irradiation infections in mice. I. The effect of streptomycin and myelopoietic-stimulating substances.
• Virologic aspects on the upper respiratory infections in childhood with special reference to nondiphtheritic croup.
• [In Process Citation]
• [Splitting of some racemic barbitals in optic antipodes. 3. On barbituric acid derivatives]