N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus.

N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus. Research Abstract Details 

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N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus. Abstract Text:

J ,E Varea,J ,M A ,E ,C Crespo,F J ,B S McEwen,

N-methyl-d-aspartate (NMDA) receptors play a crucial role in the regulation of neuronal development during embryogenesis and they also regulate the rate of neurogenesis and proliferation in the adult dentate gyrus. However, the mechanism by which they influence these processes is not fully understood. NMDA receptors seem to be functional in hippocampal precursor cells and recently generated granule neurons, although there is no anatomical correlate of these physiological observations. We have analyzed the expression of the NMDA receptor subunits NR1 and NR2B in precursor cells and recently generated granule neurons of the adult rat dentate gyrus, using 5'bromodeoxyuridine, green fluorescent protein-retrovirus and immunohistochemistry. Our results indicate that NR1 and NR2B are expressed in some proliferating cells of the adult subgranular zone. These receptors are absent from transiently amplifying progenitors (type 2-3 cells) but they are found in glial fibrillar acidic protein expressing cells in the subgranular zone, suggesting its presence in bipotential (type-1) precursor cells. NR1 and NR2B are rarely found in granule cells younger than 60 h. By contrast, many granule cells generated 14 days before killing express both NMDA receptor subunits. These results demonstrate that adult hippocampal neurogenesis may be regulated by NMDA receptors present in precursor cells and in differentiating granule neurons, although these receptors are probably not located on synapses. However, an indirect effect through NMDA receptors located in other cell types should not be excluded.

N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus. Publishing Authors By Initials

J ,E Varea,J ,MA ,E ,C Crespo,FJ ,BS McEwen,

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N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroscience

VOLUME: 144

Page Numbers: 855-64

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 8

MONTH: 12

YEAR: 2006

N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus. Information

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LANGUAGE: eng

NlmUniqueID: 7605074

N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus. Information

Substance Name: Bromodeoxyuridine

Registry Number: 59-14-3

Grant and Affiliation Information for N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus.

AFFILIATION: Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de València, Dr. Moliner 50, Burjassot 46100, Spain.

Country: United States

AGENCY: United States NIMH

GRANT: P50MH58911

ACRONYM: MH

MEDLINETA: Neuroscience

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