N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes.

N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes. Research Abstract Details 

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N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes. Abstract Text:

Troy E Reynolds,Charlotte A Stern,Karl A Scheidt,

Highly substituted alpha,beta-unsaturated ketones are prepared by the N-heterocyclic carbene-initiated addition of alpha-hydroxypropargylsilanes to aldehydes. This strategy serves as a highly efficient alternative to the standard Morita-Baylis-Hillman (MBH) approaches for these types of compounds. In contrast to the MBH reaction, different substitution in the beta-position of the product (R1) can be accommodated in moderate to excellent yields with a high degree of control over the resulting alkene.

N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes. Publishing Authors By Initials

TE Reynolds,CA Stern,KA Scheidt,

For similar inorganic chemicals: silicon compounds: silanes research abstracts see: inorganic chemicals: silicon compounds: silanes research

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N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Organic letters

VOLUME: 9

Page Numbers: 2581-4

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 1

MONTH: 06

YEAR: 2007

N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes. Information

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LANGUAGE: eng

NlmUniqueID: 100890393

N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes. Keywords Mesh Terms:

KEYWORDS: Silanes

MESH TERMS: chemistry

Chemical & Substance for Abstract: N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes. Information

Substance Name: Silanes

Registry Number: 0

Grant and Affiliation Information for N-heterocyclic carbene-initiated alpha-acylvinyl anion reactivity: additions of alpha-hydroxypropargylsilanes to aldehydes.

AFFILIATION: Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM073072

ACRONYM: GM

MEDLINETA: Org Lett

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