N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.

N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain. Research Abstract Details 

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N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain. Abstract Text:

Christopher Deur,Arun K Agrawal,Heidi Baum,John Booth,Susan Bove,Joan Brieland,Amy Bunker,Cleo Connolly,Joseph Cornicelli,JoAnn Dumin,Barry Finzel,Xinmin Gan,Sheila Guppy,Gregg Kamilar,Kenneth Kilgore,Pil Lee,Cho-Ming Loi,Zhen Lou,Mark Morris,Laurence Philippe,Sally Przybranowski,Frank Riley,Brian Samas,Brian Sanchez,Haile Tecle,Ziqiang Wang,Kathryn Welch,Michael Wilson,Karen Yates,

It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the treatment of stroke, was evaluated and further optimized with the goal of finding peripherally restricted NMDA receptor antagonists.

N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain. Publishing Authors By Initials

C Deur,AK Agrawal,H Baum,J Booth,S Bove,J Brieland,A Bunker,C Connolly,J Cornicelli,J Dumin,B Finzel,X Gan,S Guppy,G Kamilar,K Kilgore,P Lee,CM Loi,Z Lou,M Morris,L Philippe,S Przybranowski,F Riley,B Samas,B Sanchez,H Tecle,Z Wang,K Welch,M Wilson,K Yates,

For similar organic chemicals: amides: sulfonamides research abstracts see: organic chemicals: amides: sulfonamides research

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N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4599-603

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 31

MONTH: 05

YEAR: 2007

N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain. Keywords Mesh Terms:

KEYWORDS: Sulfonamides

MESH TERMS: pharmacology

Chemical & Substance for Abstract: N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain. Information

Substance Name: Sulfonamides

Registry Number: 0

Grant and Affiliation Information for N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.

AFFILIATION: Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. christopher.deur@pfizer.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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