Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1.

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. Research Abstract Details 

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Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. Abstract Text:

Francesc ,Francesc Ventura,

Bone morphogenetic protein-2 (BMP-2) induces a switch in differentiation of mesenchymal cells from the myogenic to the osteogenic lineage. Here we describe that in C2C12 cells, BMP-2 decreases myogenin expression induced by des-(1,3) insulin-like growth factor-1 (des-(1,3)IGF-1) or ectopically expressed from a constitutive promoter, even in conditions where myogenin mRNA levels were unaffected. Addition of BMP-2 decreases myogenin protein half-life to 50%, whereas proteasome inhibitors abolish these effects. Forced expression of Id1, either by transient transfection or under the control of an inducible system, causes degradation of myogenin in the absence of BMP-2. In contrast, E47 overexpression blocks the inhibitory effect of BMP-2 on myogenin levels. Finally, expression of E47 in 293 cells stabilizes myogenin, an effect that is dependent on the heterodimerization mediated by their helix-loop-helix. Our findings indicate that induction of Id1 not only blocks transcriptional activity but also induces myogenin degradation by blocking formation of myogenin-E47 protein complexes.

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. Publishing Authors By Initials

F ,F Ventura,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of biological chemistry

VOLUME: 279

Page Numbers: 45766-72

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 22

MONTH: 08

YEAR: 2004

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1.

AFFILIATION: Unitat de Bioquímica, Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, E-08907 L'Hospitalet de Llobregat, Spain.

Country: United States

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MEDLINETA: J Biol Chem

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