Myofibroblasts in focal nodular hyperplasia of the liver.

Myofibroblasts in focal nodular hyperplasia of the liver. Research Abstract Details 

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Myofibroblasts in focal nodular hyperplasia of the liver. Abstract Text:

F Callea,J Mebis,V J Desmet,

The purpose of this discussion is to document the finding of contractile fibroblasts and to examine their possible origin in a further pathological process: focal nodular hyperplasia (FNH) of the liver. A 31-year old female patient underwent laparotomy for a hypochondrial mass. The patient had been taking OCs for 1 year. The mass was located in the right lobe of the liver and excision of the tumor was performed. Some distance from it a subcapsular hemangioma was discovered and resected. After 16 months of follow-up the patient is well. The tumor mass (10 cm diameter) grey in color, was very well demarcated, although not encapsulated. A central scar was present. Radiating septa divided the periphery of the mass into multiple, variable sized modules, simulating a pattern of focal cirrhosis. No areas of hemmorhage or infraction were observed. The hemangioma specimens showed multiple cyst-like cavities filled with blood. The bosselated and lobulated appearance was because of areas of fibrosis, which was most marked centrally. Vascular changes similar to those described by Mays et al. and bile ductular proliferation analogous to that described by others were seen. Single small bile ductules were frequently observed within parenchymal nodules, without any relation to the intranodular scars. Cells with elongated, cross banded nuclei were in close vicinity of the newly formed ductules. Inflammatory and fibroblast-like cells were seen in the fibrous connective tissue septa. The 2nd lesion showed the typical features of a cavernous hemangioma. Typical fibroblasts were identified by their elongated or star-like shape, the slender fusiform shape and relatively smooth outline of the nucleus, the well developed RER and Golgi apparatus, the scattered mitochondria, and the absence or scanty presence of cytofilaments. A large number of elongated cells exhibited the characteristic morphology of modified contractile fibroblasts (MF). They showed a variable amount of intracytoplasmic microfilaments, arranged in longitudinal bundles, usually parallel to the long axis of the cell predominantly located beneath the plasma membrane. Intracellular connections between modified fibroblasts were frequently observed; they were mostly of the macula-adherens type. The finding of contractile fibroblasts raises questions concerning the origin and the significance of such cells in FNH. Since MFs are similar to both fibroblasts and smooth muscle cells, it seemed reasonable to conclude that both cells, under appropriate conditions, may become MF. Fat storing cells of Ito may also be a progenitor of contractile fibroblasts.

Myofibroblasts in focal nodular hyperplasia of the liver. Publishing Authors By Initials

F Callea,J Mebis,VJ Desmet,

For similar digestive system: liver research abstracts see: digestive system: liver research

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Myofibroblasts in focal nodular hyperplasia of the liver. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv. A, Pathological anatomy and histo

VOLUME: 396

Page Numbers: 155-66

Journal Abbreviation:

ISSN: 0340-1227

DAY: 20

MONTH: 02

YEAR: 1982

Myofibroblasts in focal nodular hyperplasia of the liver. Information

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LANGUAGE: eng

NlmUniqueID: 7505137

Myofibroblasts in focal nodular hyperplasia of the liver. Keywords Mesh Terms:

KEYWORDS: Liver

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Myofibroblasts in focal nodular hyperplasia of the liver. Information

Substance Name: Contraceptives, Oral

Registry Number: 0

Grant and Affiliation Information for Myofibroblasts in focal nodular hyperplasia of the liver.

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Country: GERMANY, WEST

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MEDLINETA: Virchows Arch A Pathol Anat Hi

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