Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease.

Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Research Abstract Details 

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Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Abstract Text:

Robert H Nelson,Abhiram Prasad,Amir Lerman,John M Miles,

Animal studies indicate that oversupply of fatty acids derived from the action of cardiac lipoprotein lipase (LPL) on plasma lipoproteins may contribute to myocardial dysfunction. However, the contribution of circulating triglycerides to myocardial fatty acid supply in humans is not known. Six postabsorptive nondiabetic subjects who were scheduled for diagnostic coronary angiography were studied. (14)C oleate and a lipid emulsion labeled with (3)H triolein were infused to assess myocardial uptake of free fatty acids (FFAs) and triglycerides, as well as myocardial spillover of LPL-generated fatty acids. Six paired blood samples were taken from the femoral artery and the coronary sinus. Coronary sinus concentrations of unlabeled triglycerides were slightly, but not significantly, lower than arterial (P = 0.12), whereas labeled triglyceride concentrations were significantly lower in the coronary sinus than in the artery (P < 0.05; extraction fraction congruent with 11%). Triglycerides and FFAs accounted for approximately 17% and approximately 83%, respectively, of myocardial fatty acid uptake. Systemic and myocardial fractional spillover of LPL-generated fatty acids was 49.0 +/- 7% and 34.7 +/- 13%, respectively. The myocardium was a minor contributor to systemic triglyceride uptake ( approximately 3%) and a trivial contributor to systemic FFA production ( approximately 0.5%). These results indicate that circulating triglycerides may be a significant source of fatty acids for myocardial respiration.

Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Publishing Authors By Initials

RH Nelson,A Prasad,A Lerman,JM Miles,

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Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetes

VOLUME: 56

Page Numbers: 527-30

Journal Abbreviation: Diabetes

ISSN: 0012-1797

DAY: 3

MONTH: Feb

YEAR: 2007

Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Information

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LANGUAGE: eng

NlmUniqueID: 372763

Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Keywords Mesh Terms:

KEYWORDS: Tritium

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Information

Substance Name: Triolein

Registry Number: 122-32-7

Grant and Affiliation Information for Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease.

AFFILIATION: Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR 00585

ACRONYM: RR

MEDLINETA: Diabetes

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