Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise.

Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise. Research Abstract Details 

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Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise. Abstract Text:

J O J Davies,B J Hunt,J O J Davies,B J Hunt,

The objective of this study was to highlight the need for investigation of antiphospholipid (aPL) antibodies in patients presenting with myocardial infarction (MI) and normal coronary arteries at angiography. We present five patients who were found to have had an MI without evidence of atherosclerosis. All had aPL antibodies and thus fulfilled the diagnosis of antiphospholipid syndrome (APS). Who did not have recurrent events on long-term anticoagulation maintaining an international normalised ratio of 3-4. This study suggests that APS is probably a major cause of MI in those with normal coronary arteries at angiography. It is an important diagnosis to make as they do not require anti-atherosclerotic treatment but appear, from this case series, to do well on high-dose warfarin. Further clinical studies are necessary to look at prevalence and best management in these patients.

Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise. Publishing Authors By Initials

JO Davies,BJ Hunt,JO Davies,BJ Hunt,

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Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of clinical practice

VOLUME: 61

Page Numbers: 379-84

Journal Abbreviation: Int. J. Clin. Pract.

ISSN: 1368-5031

DAY: 22

MONTH: Mar

YEAR: 2007

Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise. Information

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LANGUAGE: eng

NlmUniqueID: 9712381

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Grant and Affiliation Information for Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise.

AFFILIATION: Department of Intensive Care Medicine, St Thomas' Hospital, London, UK.

Country: England

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MEDLINETA: Int J Clin Pract

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