MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. Abstract Text:

Younghwa Kim,Ping Zhou,Liping Qian,Jen-Zen Chuang,Jessica Lee,Chenjian Li,Costantino Iadecola,Carl Nathan,Aihao Ding,

The innate immune system relies on evolutionally conserved Toll-like receptors (TLRs) to recognize diverse microbial molecular structures. Most TLRs depend on a family of adaptor proteins termed MyD88s to transduce their signals. Critical roles of MyD88-1-4 in host defense were demonstrated by defective immune responses in knockout mice. In contrast, the sites of expression and functions of vertebrate MyD88-5 have remained elusive. We show that MyD88-5 is distinct from other MyD88s in that MyD88-5 is preferentially expressed in neurons, colocalizes in part with mitochondria and JNK3, and regulates neuronal death. We prepared MyD88-5/GFP transgenic mice via a bacterial artificial chromosome to preserve its endogenous expression pattern. MyD88-5/GFP was detected chiefly in the brain, where it associated with punctate structures within neurons and copurified in part with mitochondria. In vitro, MyD88-5 co-immunoprecipitated with JNK3 and recruited JNK3 from cytosol to mitochondria. Hippocampal neurons from MyD88-5-deficient mice were protected from death after deprivation of oxygen and glucose. In contrast, MyD88-5-null macrophages behaved like wild-type cells in their response to microbial products. Thus, MyD88-5 appears unique among MyD88s in functioning to mediate stress-induced neuronal toxicity.

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. Publishing Authors By Initials

Y Kim,P Zhou,L Qian,JZ Chuang,J Lee,C Li,C Iadecola,C Nathan,A Ding,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: biological transport: protein transport research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: biological transport: protein transport research

PUBMED ID PMID:

MEDLINE DATE:

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of experimental medicine

VOLUME: 204

Page Numbers: 2063-74

Journal Abbreviation: J. Exp. Med.

ISSN: 0022-1007

DAY: 27

MONTH: 08

YEAR: 2007

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985109

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. Keywords Mesh Terms:

KEYWORDS: Protein Transport

MESH TERMS: enzymology

Chemical & Substance for Abstract: MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. Information

Substance Name: Mitogen-Activated Protein Kinase 10

Registry Number: EC 2.7.1.-

Grant and Affiliation Information for MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.

AFFILIATION: Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS 35806

ACRONYM: NS

MEDLINETA: J Exp Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival Related Publications

• Effects of exposing DBA/2J mice to a high-frequency augmented acoustic environment on the cochlea and anteroventral cochlear nucleus.
• Histopathologic classification of 3 476 orbital diseases.
• The compliance with nasal continuous positive airway pressure in patients with sleep apnea syndrome.
• The rise and fall of ceramide and 1,2-diacylglycerol (DAG): modulation by transforming growth factor-beta 1 (TGF beta 1) and by epidermal growth factor (EGF).
• [A study of gait recognition based on kinematics and kinetics parameters]
• [Advance of research on survivin in hematological malignancies--review]
• [Assessing the significance of platelet count to in-vitro hemolytic test by roller pump]
• [Chiral separation of racemic 5-(p-hydroxyphenyl)-5-phenylhydantoin by RP-HPLC using eluents containing beta-cyclodextrin]
• [Cloning and expression of ethylene receptor gene Ad-ETR1 from kiwifruit.]
• [Cloning and permanent expression in eukaryotic cells of rhTpo]
• [Colleagues Association: A medical organization in modern Japan]
• [Construction of the full-length cDNA clone of Chinese virulent strain--F114]
• [Effects of allogeneic hepatic nonparenchymal cell on the survival of grafted skin in mice]
• [Elution behaviors of cations on the serial columns combining a cation exchange column with an ion exclusion column]
• [Expression of vascular endothelial growth factor in patients with aplastic anemia and its significance]
• [Fate of massive retrieved human bone allografts]
• [High level Le Fort I osteotomy and bone grafting for correction of secondary mid-face deformities in cleft patients]
• [Indications for colonoscopy examination and its disease distribution: a report of 5690 cases]
• [Oxidative stress status in patients with various degrees of chronic renal insufficiency]
• [Pay close attention to and strengthen studies on medical issues related to girlschild]
• [Physiological maturity and early development of children]
• [Preliminary analysis of chromosome abnormalities in breast mammary phyllodes tumour by comparative genomic hybridization (CGH)]
• [Protective effects of amifostine on hematopoietic stem/progenitor cells against chemotherapeutic damage]
• [Reproductive expectation and gender preferences of parents in poverty areas of China]
• [Research advances of adult stem cells and dental stem cells]
• [Role of interleukin-9 in the pathogenesis of chronic obstructive pulmonary disease]
• [Screening of stage-specific expression genes of Spirometra erinacei-europaei plerocercoid by mRNA differential display technique]
• [Small-invasive photoelectric detection of blood glucose]
• [The research on the chemical components of Schizonepeta tenuifolia Briq.]
• [Valsartan eluting-stents inhibited neointimal hyperplasia by decreasing collagen deposition in rabbits]