MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells.

MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Research Abstract Details 

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MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Abstract Text:

Jung-Hee Kang,Piotr G Rychahou,Titilope A Ishola,Jingbo Qiao,B Mark Evers,Dai H Chung,

MYCN amplification strongly correlates with unfavorable outcomes in patients with neuroblastoma. The aim of this study was to investigate the role of MYCN in neuroblastoma cell differentiation and apoptosis. We used the technique of RNA interference to inhibit MYCN gene expression in neuroblastoma cells with variable expression of MYCN. Our results showed that inhibition of MYCN gene expression in MYCN amplified cells induced apoptosis and suppressed cell growth; neuronal differentiation also occurred after MYCN gene silencing. Moreover, N-myc downregulation was associated with decreased Bcl-xL protein levels and caspase-3 activation. These data show that small interfering RNA directed to MYCN, which plays a crucial role in neuroblastoma cell survival, may provide a potential novel therapeutic option for aggressive neuroblastomas.

MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Publishing Authors By Initials

JH Kang,PG Rychahou,TA Ishola,J Qiao,BM Evers,DH Chung,

For similar proteins: neoplasm proteins: oncogene proteins research abstracts see: proteins: neoplasm proteins: oncogene proteins research

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MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 351

Page Numbers: 192-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 12

MONTH: 10

YEAR: 2006

MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Information

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LANGUAGE: eng

NlmUniqueID: 372516

MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Keywords Mesh Terms:

KEYWORDS: Oncogene Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Information

Substance Name: Oncogene Proteins

Registry Number: 0

Grant and Affiliation Information for MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells.

AFFILIATION: Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK61470

ACRONYM: DK

MEDLINETA: Biochem Biophys Res Commun

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