MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment.

MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. Abstract Text:

Xiao-Fei Kong,Xin-Xin Zhang,Qi-Ming Gong,Jian Gao,Shen-Ying Zhang,Lin Wang,Jie Xu,Yue Han,Gen-Di Jin,Jie-Hong Jiang,Dong-Hua Zhang,Zhi-Meng Lu,Xiao-Fei Kong,Xin-Xin Zhang,Qi-Ming Gong,Jian Gao,Shen-Ying Zhang,Lin Wang,Jie Xu,Yue Han,Gen-Di Jin,Jie-Hong Jiang,Dong-Hua Zhang,Zhi-Meng Lu,

The objective of this study was to find potential biomarkers for predicting sustained virologic responses to interferon-alpha (IFN-alpha) treatment in chronic hepatitis B (CHB) patients. A total of 101 CHB patients were treated with pegylated IFN-alpha2a for 48 weeks and followed up for 24 weeks, including 34 IFN responders (IFN-Rs) and 67 IFN nonresponders (IFN-NRs). After peripheral blood mononuclear cells (PBMCs) and Epstein-Barr virus-transferred B (EBV-B) cell lines were treated with different concentrations of IFN-alpha in vitro, activated IFN-stimulated gene factor3 (ISGF3) and IFN-gamma-activation factor (GAF) were measured by EMSA, and MxA, OAS1, and PKR mRNA were measured by real-time PCR. Polymorphisms in the MxA promoter were genotyped to find the possible association. IFN-alpha-activated ISGF3 and GAF levels were similar between IFN-NRs and IFN-Rs. However, MxA mRNA induction in IFN-Rs was higher than that in IFN-NRs, and such discrepancy increased when highly concentrated IFN was used to stimulate. The OAS1 and PKR mRNA induction have a similar pattern between IFN-Rs and IFN-NRs. In addition, frequency of the MxA-88G/T genotype was significantly different between IFN-Rs and IFN-NRs, and this polymorphism was also functional because MxA mRNA induction in patients with GG genotype was lower than those with GT genotype. Regression analysis showed that MxA mRNA induction after 10,000 IU/mL IFN stimulation could serve as an independent factor for predicting IFN-alpha, with an area under curve (AUC) of 0.838, a positive predictive value of 68% for IFN-Rs, and a negative predictive value of 89% for IFN-NRs. MxA mRNA induced by IFN-alpha might predict sustained virologic responses to IFN-alpha treatment in CHB patients.

MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. Publishing Authors By Initials

XF Kong,XX Zhang,QM Gong,J Gao,SY Zhang,L Wang,J Xu,Y Han,GD Jin,JH Jiang,DH Zhang,ZM Lu,XF Kong,XX Zhang,QM Gong,J Gao,SY Zhang,L Wang,J Xu,Y Han,GD Jin,JH Jiang,DH Zhang,ZM Lu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of interferon & cytokine research : the of

VOLUME: 27

Page Numbers: 809-18

Journal Abbreviation: J. Interferon Cytokine Res.

ISSN: 1079-9907

DAY: 25

MONTH: Sep

YEAR: 2007

MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9507088

MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment.

AFFILIATION: Department of Infectious Disease, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Interferon Cytokine Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment Related Publications

• Educational diagnosis of self-management behaviors of parents with asthmatic children by triangulation based on PRECEDE-PROCEED model in Taiwan.
• Effect of transforming growth factor-beta(2) on extracellular matrix synthesis in bovine trabecular meshwork cells.
• Influence of abnormal cervical pap smear undertaken during pregnancy to the outcome of the pregnancy.
• WT1 downregulation during K562 cell differentiation and apoptosis induced by bufalin.
• [Analysis of three-dimensional microstructure of poly(lactide-co-glycolide) scaffolds made by mild heating under high pressure]
• [Changes in plasma levels of adrenomedullin and cyclic adenosine monophosphate and their interrelation in patients with chronic heart failure]
• [Clinical significance of serum troponin I in patients with acute left heart failure]
• [Cloning and expression of the gene of recombinant augmenter of liver regeneration in yeast]
• [Collection, processing and cryopreservation of placental cord blood hematopoietic stem cells]
• [Construction of pcDNA3.1AM and expression of adrenomedullin in mammalian cells]
• [Cytogenetic analysis on 1058 cases of acute nonlymphocytic leukemia]
• [Determination of domoic acid in water and aquatic animals by high performance liquid chromatography]
• [Diagnosing achondroplasia by single cell nested-PCR]
• [Different effects of acetylcholine on the action potential and force contraction in guinea pig atrial and ventricular myocardium]
• [Effect of tumor necrosis factor-alpha on differentiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat]
• [Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit]
• [Human leukocyte antigen mismatched hemopietic stem cell transplants for the treatment of leukemia]
• [Human peripheral blood monocyte derived dendritic cell culture and mature regulation]
• [Inhibition of proliferation and induction of apoptosis by simvastatin in K562 leukemic cell line]
• [MK-801 suppresses dynorphin A (1-17)-induced facilitation of nociceptive responses to formalin in rats]
• [Molecular cytogenetic detection of partial chromosome 13q trisomy and its relation with the clinical features of tortilcollis]
• [Non-Hodgkin's lymphoma in the lacrimal gland: report of one case]
• [Reactive oxygen species and mitochondrial KATP-sensitive channels mediated cardioprotection induced by TNF-alpha during hypoxia and reoxygenation]
• [Relationship between soluble Fas ligand levels and complications after allogeneic bone marrow transplantation]
• [Relationship of I/D polymorphism of angiotensin converting enzyme gene with hypertension in Xinjiang Kazakh isolated group]
• [Sequencing of the glyceraldehyde-3-phosphate dehydrogenase gene from Plasmodium falciparum strain FCC1/HN]
• [Study on defibrinogenasing enhancing the thrombolytic effect of urokinase on acute myocardial infarction]
• [Study on preparation of beta-cyclodextrin inclusion compound of volatile oil from Aucklandia lappa]
• [The determination of F-, Cl-, NO3- and SO(4)2- in the total suspended particles in air by ion chromatography]
• [Treatment of primary trauma in the brainstem: analysis of 126 cases]