Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance.

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Research Abstract Details 

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Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Abstract Text:

C Bubici,S Papa,K Dean,G Franzoso,

Reactive oxygen species (ROS) are emerging as key effectors in signal transduction. This role of ROS is especially evident in the pathways leading to programmed cell death (PCD) elicited in response to certain stress stimuli and cytokines. In these pathways, cytotoxic ROS signaling appears to be mediated in part by activation of the c-Jun-N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) cascade. Another pathway that is under ROS-mediated control in some systems is that leading to activation of transcription factor nuclear factor-kappa B (NF-kappaB), which is a central regulator of immunity, inflammation and cell survival. Remarkably, new evidence has unveiled the existence of a reciprocal, negative control that NF-kappaB exerts on ROS and JNK activities. This NF-kappaB-imposed restraint on ROS and JNK signaling is crucial for antagonism of PCD elicited by the proinflammatory cytokine tumor necrosis factor (TNF)alpha and likely other triggers. Effectors of this antagonistic cross-talk between NF-kappaB and ROS/JNK pathways have recently been identified. Because of the key roles that the prosurvival function of NF-kappaB plays in organismal physiology and disease, gaining a further mechanistic understanding of this cross-talk and NF-kappaB-dependent survival may be key to developing new therapies for the treatment of widespread human illnesses, such as cancer and chronic inflammatory conditions.

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Publishing Authors By Initials

C Bubici,S Papa,K Dean,G Franzoso,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Journal Published:

PUBLICATION TYPE: Review

Journal: Oncogene

VOLUME: 25

Page Numbers: 6731-48

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 30

MONTH: Oct

YEAR: 2006

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Information

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LANGUAGE: eng

NlmUniqueID: 8711562

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Information

Substance Name: MAP Kinase Kinase 4

Registry Number: EC 2.7.1.-

Grant and Affiliation Information for Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance.

AFFILIATION: The Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.

Country: England

AGENCY: United States NCI

GRANT: R01-CA84040

ACRONYM: CA

MEDLINETA: Oncogene

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