Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.

Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Research Abstract Details 

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Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Abstract Text:

Jasper Harris,Mia Lowden,Iuval Clejan,Monika Tzoneva,James H Thomas,Jonathan Hodgkin,Shawn Ahmed,

DNA damage response proteins identify sites of DNA damage and signal to downstream effectors that orchestrate either apoptosis or arrest of the cell cycle and DNA repair. The C. elegans DNA damage response mutants mrt-2, hus-1, and clk-2(mn159) displayed 8- to 15-fold increases in the frequency of spontaneous mutation in their germlines. Many of these mutations were small- to medium-sized deletions, some of which had unusual sequences at their breakpoints such as purine-rich tracts or direct or inverted repeats. Although DNA-damage-induced apoptosis is abrogated in the mrt-2, hus-1, and clk-2 mutant backgrounds, lack of the apoptotic branch of the DNA damage response pathway in cep-1/p53, ced-3, and ced-4 mutants did not result in a Mutator phenotype. Thus, DNA damage checkpoint proteins suppress the frequency of mutation by ensuring that spontaneous DNA damage is accurately repaired in C. elegans germ cells. Although DNA damage response defects that predispose humans to cancer are known to result in large-scale chromosome aberrations, our results suggest that small- to medium-sized deletions may also play roles in the development of cancer.

Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Publishing Authors By Initials

J Harris,M Lowden,I Clejan,M Tzoneva,JH Thomas,J Hodgkin,S Ahmed,

For similar proteins: dna-binding proteins: telomere-binding proteins research abstracts see: proteins: dna-binding proteins: telomere-binding proteins research

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Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genetics

VOLUME: 174

Page Numbers: 601-16

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 1

MONTH: 09

YEAR: 2006

Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374636

Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Keywords Mesh Terms:

KEYWORDS: Telomere-Binding Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Information

Substance Name: clk-2 protein, C elegans

Registry Number: 0

Grant and Affiliation Information for Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.

AFFILIATION: Department of Biology, University of North Carolina, NC 27599-3280, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM066228

ACRONYM: GM

MEDLINETA: Genetics

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