Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.

Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Research Abstract Details 

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Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Abstract Text:

Shigekazu Tanaka,Ikuo Miura,Atsushi Yoshiki,Yoriko Kato,Haruka Yokoyama,Akiko Shinogi,Hiroshi Masuya,Shigeharu Wakana,Masaru Tamura,Toshihiko Shiroishi,Shigekazu Tanaka,Ikuo Miura,Atsushi Yoshiki,Yoriko Kato,Haruka Yokoyama,Akiko Shinogi,Hiroshi Masuya,Shigeharu Wakana,Masaru Tamura,Toshihiko Shiroishi,Shigekazu Tanaka,Ikuo Miura,Atsushi Yoshiki,Yoriko Kato,Haruka Yokoyama,Akiko Shinogi,Hiroshi Masuya,Shigeharu Wakana,Masaru Tamura,Toshihiko Shiroishi,

Two classical mouse hair coat mutations, Rex (Re) and Rex wavy coat (Re(wc)), are linked to the type I inner root sheath (IRS) keratin genes of chromosome 11. An N-ethyl-N-nitrosourea-induced mutation, M100573, also maps close to the type I IRS keratin genes. In this study, we demonstrate that Re and M100573 mice bear mutations in the type I IRS gene Krt25; Re(wc) mice bear an additional mutation in the type I IRS gene Krt27. These three mutations are located in the helix termination motif of the 2B alpha-helical rod domain of a type I IRS keratin protein. Immunohistological analysis revealed abnormal foam-like immunoreactivity with an antibody raised to type II IRS keratin K71 in the IRS of Re/+ mice. These results suggest that the helix termination motif is essential for the proper assembly of types I and II IRS keratin protein complexes and the formation of keratin intermediate filaments.

Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Publishing Authors By Initials

S Tanaka,I Miura,A Yoshiki,Y Kato,H Yokoyama,A Shinogi,H Masuya,S Wakana,M Tamura,T Shiroishi,S Tanaka,I Miura,A Yoshiki,Y Kato,H Yokoyama,A Shinogi,H Masuya,S Wakana,M Tamura,T Shiroishi,S Tanaka,I Miura,A Yoshiki,Y Kato,H Yokoyama,A Shinogi,H Masuya,S Wakana,M Tamura,T Shiroishi,

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Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genomics

VOLUME: 90

Page Numbers: 703-11

Journal Abbreviation: Genomics

ISSN: 0888-7543

DAY: 24

MONTH: 10

YEAR: 2007

Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Information

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LANGUAGE: eng

NlmUniqueID: 8800135

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Grant and Affiliation Information for Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.

AFFILIATION: Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka, Japan.

Country: United States

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MEDLINETA: Genomics

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ACCESSION NUMBER: AB288231

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