Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly.

Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Research Abstract Details 

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Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Abstract Text:

Marie Fernandes,Grigoriy Gutin,Heather Alcorn,Susan K McConnell,Jean M ,Marie Fernandes,Grigoriy Gutin,Heather Alcorn,Susan K McConnell,Jean M ,Marie Fernandes,Grigoriy Gutin,Heather Alcorn,Susan K McConnell,Jean M ,

Holoprosencephaly (HPE) is a devastating forebrain abnormality with a range of morphological defects characterized by loss of midline tissue. In the telencephalon, the embryonic precursor of the cerebral hemispheres, specialized cell types form a midline that separates the hemispheres. In the present study, deletion of the BMP receptor genes, Bmpr1b and Bmpr1a, in the mouse telencephalon results in a loss of all dorsal midline cell types without affecting the specification of cortical and ventral precursors. In the holoprosencephalic Shh(-/-) mutant, by contrast, ventral patterning is disrupted, whereas the dorsal midline initially forms. This suggests that two separate developmental mechanisms can underlie the ontogeny of HPE. The Bmpr1a;Bmpr1b mutant provides a model for a subclass of HPE in humans: midline inter-hemispheric HPE.

Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Publishing Authors By Initials

M Fernandes,G Gutin,H Alcorn,SK McConnell,JM ,M Fernandes,G Gutin,H Alcorn,SK McConnell,JM ,M Fernandes,G Gutin,H Alcorn,SK McConnell,JM ,

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Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 3789-94

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 3

MONTH: 10

YEAR: 2007

Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly.

AFFILIATION: Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Country: England

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MEDLINETA: Development

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