Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein.

Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein. Research Abstract Details 

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Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein. Abstract Text:

C Marchal,J M Clement,M Hofnung,

Results obtained in E. coli with a set of mutations conferring tight resistance to phage lambda lead to a first identification of three residues in the lamB protein which are important for adsorption of phage lambda. Residues 151 and 382 are important for reversible adsorption while residue 401 is important for irreversible adsorption. The identification of such residues may help to identify portions of the protein located at the cell surface. Assays of lambda receptor activity in merodiploid strains heterogenote for gene lamB show that the mutations studied can have a negative dominant effect. For one class of mutations (class II) this can be interpreted by negative complementation at the level of oligomerisation. The data confirm then that active lambda receptor is a trimer.

Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein. Publishing Authors By Initials

C Marchal,JM Clement,M Hofnung,

For similar proteins: membrane proteins: receptors, cell surface: receptors, virus research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, virus research

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Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Tokai journal of experimental and clinical med

VOLUME: 7 Suppl

Page Numbers: 165-70

Journal Abbreviation: Tokai J. Exp. Clin. Med.

ISSN: 0385-0005

DAY: 27

MONTH: 11

YEAR: 1982

Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein. Information

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LANGUAGE: eng

NlmUniqueID: 7704186

Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein. Keywords Mesh Terms:

KEYWORDS: Receptors, Virus

MESH TERMS: genetics

Chemical & Substance for Abstract: Mutations in gene lamB: studies on structure and topology of an E. coli outer membrane protein. Information

Substance Name: maltoporins

Registry Number: 0

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Country: JAPAN

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MEDLINETA: Tokai J Exp Clin Med

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